Effect of local hyperthermia of the bladder on mitomycin C pharmacokinetics during intravesical chemotherapy for the treatment of superficial transitional cell carcinoma

Rita Paroni, Andrea Salonia, Avigdor Lev, Luigi Filippo Da Pozzo, Giuliana Cighetti, Francesco Montorsi, Patrizio Rigatti, Renzo Colombo

Research output: Contribution to journalArticle

Abstract

Aims To assess the effect of local hyperthermia on the systemic absorption of mitomycin C (MMC) during intravesical chemotherapy for the treatment of superficial transitional cell carcinoma of the bladder, and to establish the likely safety of this procedure. Methods Group 1 (n= 12) received 20 mg intravesical MMC plus local hyperthermia, group 2 (n =13) 20 mg MMC alone, group 3 (n=16) 40 mg MMC plus local hyperthermia and group 4 (n= 10) 40 mg MMC alone. Patients in groups 1, 2, and 4 underwent post-tumour resection adjuvant treatment, whereas those in group 3 still had tumour present and were treated" to eradicate it. Intravesical instillation lasted 60 min, with the solution (50 ml) being replaced after the first 30 min. Blood samples were taken before, and every 15 min during instillation. MMC concentrations in plasma and in urine were determined by h.p.l.c. Results The highest MMC plasma concentration (67.9 ng ml-1) occurred in a patient in group 3. This value was well below the threshold concentration (400 ng ml-1) for myelosuppression. Local hyperthermia associated with the intravesical chemotherapy enhanced plasma MMC concentrations at 30, 45 and 60 min compared with chemotherapy alone (Group 1 vs 2, P

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalBritish Journal of Clinical Pharmacology, Supplement
Volume52
Issue number3
Publication statusPublished - 2001

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Keywords

  • Bladder hyperthermia
  • H.P.L.C
  • Intravesical chemotherapy
  • Superficial transitional cell carcinoma
  • Systemic absorption

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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