Effect of lonidamine on human malignant gliomas

Biochemical studies

Marco G. Paggi, Carmine M. Carapella, Maurizio Fanciulli, Carlo Del Carlo, Sergio Giorno, Gabriella Zupi, Bruno Silvestrini, Antonio Caputo, Aristide Floridi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while in grade III, IV and glioblastoma multiforme lactate production is inhibited. In an attempt to explain this different behaviour, hexokinase content and compartmentation was evaluated in astrocytomas from fresh operatory specimens and from cultured cells as well, observing a significative correlation between malignancy, hexokinase activity, percent of mitochondrially-bound hexokinase and LND effect. The results justify from a biochemical point of view the role of LND as a 'non-conventional' agent in multimodality combined treatment for malignant gliomas.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalJournal of Neuro-Oncology
Volume6
Issue number3
DOIs
Publication statusPublished - Nov 1988

Fingerprint

Glioma
Astrocytoma
Hexokinase
Lactic Acid
Neoplasms
Glycolysis
Glioblastoma
Cultured Cells
lonidamine

Keywords

  • astrocytoma
  • glycolysis
  • hexokinase
  • Lonidamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Effect of lonidamine on human malignant gliomas : Biochemical studies. / Paggi, Marco G.; Carapella, Carmine M.; Fanciulli, Maurizio; Del Carlo, Carlo; Giorno, Sergio; Zupi, Gabriella; Silvestrini, Bruno; Caputo, Antonio; Floridi, Aristide.

In: Journal of Neuro-Oncology, Vol. 6, No. 3, 11.1988, p. 203-209.

Research output: Contribution to journalArticle

Paggi, MG, Carapella, CM, Fanciulli, M, Del Carlo, C, Giorno, S, Zupi, G, Silvestrini, B, Caputo, A & Floridi, A 1988, 'Effect of lonidamine on human malignant gliomas: Biochemical studies', Journal of Neuro-Oncology, vol. 6, no. 3, pp. 203-209. https://doi.org/10.1007/BF00163702
Paggi, Marco G. ; Carapella, Carmine M. ; Fanciulli, Maurizio ; Del Carlo, Carlo ; Giorno, Sergio ; Zupi, Gabriella ; Silvestrini, Bruno ; Caputo, Antonio ; Floridi, Aristide. / Effect of lonidamine on human malignant gliomas : Biochemical studies. In: Journal of Neuro-Oncology. 1988 ; Vol. 6, No. 3. pp. 203-209.
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