Effect of loperamide on lower oesophageal sphincter pressure in idiopathic achalasia

R. Penagini, B. Bartesaghi, G. Negri, P. A. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Penagini R, Bartesaghi B, Negri G, Bianchi PA. Effect of loperamide on lower oesophageal sphincter pressure in idiopathic achalasia. Scand J Gastroenterol 1994;29:1057-1060. Background: We have recently shown that in achalasia patients morphine has a striking inhibitory action on resting lower oesophageal sphincter (LOS) pressure, which is mediated by opioid receptors. The aim of this study was to investigate the effect of a peripheral opioid agonist, loperamide, administered at a dose of 16 mg, on resting LOS pressure in nine patients with untreated idiopathic achalasia. Methods: All patients underwent two experiments after oral administration of placebo and loperamide, respectively, on separate days and in randomized order. At the end of the placebo experiment we also tested the effect of loperamide as compared with distilled water, both infused intraluminally at the level of the LOS. In the loperamide experiment, after a 60-min basal period, naloxone, 40 μg/kg, was injected intravenously, and recordings continued for a further 10min. Results: Loperamide administered orally decreased (p

Original languageEnglish
Pages (from-to)1057-1060
Number of pages4
JournalScandinavian Journal of Gastroenterology
Volume29
Issue number12
DOIs
Publication statusPublished - 1994

Keywords

  • Naloxone
  • Oesophageal achalasia
  • Oesophageal function
  • Opioids

ASJC Scopus subject areas

  • Gastroenterology

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