Effect of low-dose heparin on fibrinogen levels in patients with chronic ischemic heart disease

D. Prisco, R. Paniccia, B. Bandinelli, A. M. Gori, M. Attanasio, B. Giusti, M. Comeglio, R. Abbate, G. F. Gensini, G. G. Neri Serneri

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Several prospective studies have demonstrated that high plasma fibrinogen levels are associated with an increased risk of ischemic heart disease. Since in most patients an increased thrombin generation has been reported, we investigated whether the control of thrombin generation could affect plasma fibrinogen levels. Forty male outpatients (20 asymptomatic with previous myocardial infarction and 20 with stable effort angina) were enrolled in a randomized medium-term (6 months)cross-over study. Clottable fibrinogen, according to Clauss, prothrombin fragment 1+2, thrombin-antithrombin complex, and fibrinopeptide A were evaluated in relation to treatment with low-dose heparin. After a 15-day wash-out period, during which patients had been treated only with nitrates if needed, patients were allocated to two sequential periods of treatment with standard heparin (12,500 U, subcutaneously daily) plus antianginal treatment or antianginal treatment alone, separated by a second 15-day wash-out period. At the end of the treatment period with low-dose heparin significant decreases in the plasma fibrinogen (2.5 ± 0.6 g/1 vs. 3.3 ± 0.5 g/l, P

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalInternational Journal of Clinical & Laboratory Research
Issue number3
Publication statusPublished - Sep 1998


  • Fibrinogen
  • Fibrinopeptide A
  • Heparin
  • Prothrombin fragment 1+2
  • Thrombin-antithrombin complex

ASJC Scopus subject areas

  • Clinical Biochemistry


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