Effect of low-dose tamoxifen after surgical excision of ductal intraepithelial neoplasia: Results of a large retrospective monoinstitutional cohort study

A. Guerrieri-Gonzaga, M. Lazzeroni, E. Botteri, D. Serrano, N. Rotmensz, M. C. Varricchio, M. Cazzaniga, G. Bollani, S. Mora, C. Montefrancesco, G. Pruneri, G. Viale, M. Intra, V. Galimberti, A. Goldhirsch, V. Bagnardi, B. Bonanni, A. DeCensi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Postsurgical treatment of ductal intraepithelial neoplasia (DIN) with standard doses of tamoxifen has not reached a consensus yet. Given positive results of low-dose tamoxifen on breast cancer biomarkers modulation, we analyzed a large cohort of DIN patients treated with low-dose tamoxifen or no treatment as per institutional guidelines. Patients and methods: All consecutive women operated on at the European Institute of Oncology for estrogen receptor (ER)-positive DIN (474 treated with low-dose tamoxifen and 509 untreated patients) were followed up for a median of 7 years.

Original languageEnglish
Article numbermdt113
Pages (from-to)1859-1866
Number of pages8
JournalAnnals of Oncology
Volume24
Issue number7
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Breast cancer
  • Compliance
  • Dcis
  • Din
  • Low-dose tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Hematology

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