Effect of maternal human immunodeficiency virus status on the outcome of neonates with necrotizing enterocolitis

Jonathan Saul Karpelowsky, Stefanie van Mil, Alp Numanoglu, Ernesto Leva, Alastair J W Millar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: The aim of the study was to assess the impact of human immunodeficiency virus (HIV) exposure on survival and extent of disease in necrotizing enterocolitis (NEC). Patients and Methods: All patients with NEC requiring surgery between June 1998 and June 2008 were analyzed. Three groups were identified: those born to HIV-positive (HIV+) mothers, those born to HIV-negative (HIV-) mothers, and those with an unknown HIV status. Primary outcome measure was survival to discharge. Secondary outcome measure was extent of disease. Results: One hundred nine infants (mean gestational age, 31 weeks; birth weight, 1413 g) underwent surgery for NEC. Gestational age, birth weight, and day of presentation were similar in all 3 groups, showing no statistical difference. The HIV+ group consisted of 22 infants, of which 13 (59%) died and 2 (9%) had panintestinal necrosis. The HIV- group consisted of 48 infants, of which 11 (23%) died, with 3(6%) having panintestinal necrosis. The remaining group of HIV (unknown) consisted of 38 infants, of which 14 (37%) died, with 2 (5%) having panintestinal necrosis. The latter group was not included in the analysis; but comparing the HIV+ and HIV- groups, there was a statistically higher chance of death (odds ratio = 4.8, P = .05). There was no difference statistically in the extent of disease. Conclusion: Neonates with NEC born to HIV+ mothers have a higher mortality.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalJournal of Pediatric Surgery
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2010

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Necrotizing Enterocolitis
Mothers
HIV
Newborn Infant
Necrosis
Birth Weight
Gestational Age
Outcome Assessment (Health Care)
Survival
Odds Ratio

Keywords

  • AIDS
  • HIV
  • Infection
  • Necrotizing enterocolitis

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of maternal human immunodeficiency virus status on the outcome of neonates with necrotizing enterocolitis. / Karpelowsky, Jonathan Saul; van Mil, Stefanie; Numanoglu, Alp; Leva, Ernesto; Millar, Alastair J W.

In: Journal of Pediatric Surgery, Vol. 45, No. 2, 02.2010, p. 315-318.

Research output: Contribution to journalArticle

Karpelowsky, Jonathan Saul ; van Mil, Stefanie ; Numanoglu, Alp ; Leva, Ernesto ; Millar, Alastair J W. / Effect of maternal human immunodeficiency virus status on the outcome of neonates with necrotizing enterocolitis. In: Journal of Pediatric Surgery. 2010 ; Vol. 45, No. 2. pp. 315-318.
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