Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: A cross-sectional study

C. L. Lafortuna, F. Prinelli, F. Adorni, F. Agosti, A. De Col, A. Sartorio

Research output: Contribution to journalArticle


Background: Mechanical overload and poor quality of contractile elements related to metabolic abnormalities concur to motor disability of obesity. The independent contribution of these factors to motor dysfunction in obese individuals is scarcely defined. Aim: Aim of the study is to test the hypothesis that metabolic factors may independently affect motor function in obesity. Methods: Leg maximum power output per unit body mass (ẆMb), per unit fat-free mas (ẆFFM) and fatigue in daily functioning were assessed in 635 obese [body mass index (BMI)≥35 kg/m2] individuals (286 men, 349 women) aged 19-78 yr. The independent effects of age, BMI, insulin resistance and the five components of the metabolic syndrome on ẆMb, ẆFFM and fatigue were evaluated by multivariate analysis. Results: A multiple regression analysis revealed that in both genders ẆMb (denoting the individual's performance capability during anaerobic tasks) was independently reduced by age (p

Original languageEnglish
Pages (from-to)1062-1068
Number of pages7
JournalJournal of Endocrinological Investigation
Issue number11
Publication statusPublished - Dec 2013



  • Glucose homeostasis
  • Muscle power output
  • Muscle quality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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