Effect of medroxyprogesterone acetate upon pha, con a and pwm stimulated lymphocytes and on e-rosette function

G. Corsini, F. Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated if Medroxyprogesterone acetate (MPA) had an immunosuppressive action as progesterone and. other steroid hormones. Lymphocyte function was evaluated by the blastogenic response to mitogens and by the E-rosette test. MPA was tested at 7 ng/ml and 100 ng/d concentrations. Cells were either preincuhted for 30 min., 90 min., 180 min. and 12 hr or incubated with MPA for 72 hr, 18 hr and 16 hr. MPA showed a significative inhibitory effect only when used at the concentration of 100 ng/ml.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalImmunopharmacology and Immunotoxicology
Volume4
Issue number3
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

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