TY - JOUR
T1 - Effect of medroxyprogesterone acetate upon pha, con a and pwm stimulated lymphocytes and on e-rosette function
AU - Corsini, G.
AU - Puppo, F.
PY - 1982
Y1 - 1982
N2 - We evaluated if Medroxyprogesterone acetate (MPA) had an immunosuppressive action as progesterone and. other steroid hormones. Lymphocyte function was evaluated by the blastogenic response to mitogens and by the E-rosette test. MPA was tested at 7 ng/ml and 100 ng/d concentrations. Cells were either preincuhted for 30 min., 90 min., 180 min. and 12 hr or incubated with MPA for 72 hr, 18 hr and 16 hr. MPA showed a significative inhibitory effect only when used at the concentration of 100 ng/ml.
AB - We evaluated if Medroxyprogesterone acetate (MPA) had an immunosuppressive action as progesterone and. other steroid hormones. Lymphocyte function was evaluated by the blastogenic response to mitogens and by the E-rosette test. MPA was tested at 7 ng/ml and 100 ng/d concentrations. Cells were either preincuhted for 30 min., 90 min., 180 min. and 12 hr or incubated with MPA for 72 hr, 18 hr and 16 hr. MPA showed a significative inhibitory effect only when used at the concentration of 100 ng/ml.
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U2 - 10.3109/08923978209026438
DO - 10.3109/08923978209026438
M3 - Article
AN - SCOPUS:84907115946
VL - 4
SP - 247
EP - 253
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 3
ER -