Effect of melatonin on sleep microstructure: Preliminary results in healthy subjects

L. Ferini-Strambi, M. Zucconi, G. Biella, B. Stankov, F. Fraschini, A. Oldani, S. Smirne

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The ability of melatonin (MLT) to potentiate the effects of γ- aminobutyric acid and the benzodiazepines has been demonstrated repeatedly in animal models, and recent experimental data favored the hypothesis that MLT, given together with threshold doses of benzodiazepines, could significantly improve the quality of sleep. This preliminary study was designed to compare the effects of MLT (100 mg) with those of a benzodiazepine hypnotic [triazolam (TRI) 0.125 mg] and to explore the effects of a combination of MLT and TRI at a low dose in healthy volunteers. No significant changes in the classical polysomnographic variables were observed following MLT, TRI and MLT + TRI, whereas MLT and especially MLT + TRI resulted in significant modulation of some microstructural parameters. These changes were paralleled by ameliorated subjective sleep quality. A combination of MLT and low benzodiazepine doses could avoid the residual, dose-related benzodiazepine effects.

Original languageEnglish
Pages (from-to)744-747
Number of pages4
JournalSleep
Volume16
Issue number8
Publication statusPublished - 1993

Fingerprint

Melatonin
Healthy Volunteers
Sleep
Triazolam
Benzodiazepines
Aminobutyrates
Aptitude
Hypnotics and Sedatives
Animal Models

Keywords

  • Melatonin
  • Sleep microstructure

ASJC Scopus subject areas

  • Physiology

Cite this

Ferini-Strambi, L., Zucconi, M., Biella, G., Stankov, B., Fraschini, F., Oldani, A., & Smirne, S. (1993). Effect of melatonin on sleep microstructure: Preliminary results in healthy subjects. Sleep, 16(8), 744-747.

Effect of melatonin on sleep microstructure : Preliminary results in healthy subjects. / Ferini-Strambi, L.; Zucconi, M.; Biella, G.; Stankov, B.; Fraschini, F.; Oldani, A.; Smirne, S.

In: Sleep, Vol. 16, No. 8, 1993, p. 744-747.

Research output: Contribution to journalArticle

Ferini-Strambi, L, Zucconi, M, Biella, G, Stankov, B, Fraschini, F, Oldani, A & Smirne, S 1993, 'Effect of melatonin on sleep microstructure: Preliminary results in healthy subjects', Sleep, vol. 16, no. 8, pp. 744-747.
Ferini-Strambi, L. ; Zucconi, M. ; Biella, G. ; Stankov, B. ; Fraschini, F. ; Oldani, A. ; Smirne, S. / Effect of melatonin on sleep microstructure : Preliminary results in healthy subjects. In: Sleep. 1993 ; Vol. 16, No. 8. pp. 744-747.
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