Effect of metergoline, a specific antiserotoninergic agent, on GH secretion

A. E. Pontiroli, F. Cavagnini, M. Peracchi

Research output: Contribution to journalArticlepeer-review


The role of serotonin (5 HT) in the control of growth hormone (GH) secretion has not yet been clarified. 5 HT and its precursor 5 hydroxytryptophan (5 HTP) have been reported to elicit GH release, or to be ineffective, while tryptophan has been shown to blunt GH response to insulin hypoglycemia. On the other hand, cyproheptadine and methysergide, two anti 5 HT agents, have been reported to reduce insulin induced GH release. In the present study the effect of metergoline, a specific and long lasting anti 5 HT agent was evaluated. The results do not support the concept of a stimulatory role of 5 HT on GH release.

Original languageEnglish
Pages (from-to)95-96
Number of pages2
JournalHormone and Metabolic Research
Issue number1
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology


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