TY - JOUR
T1 - Effect of metergoline, a specific serotonin antagonist, on human growth hormone response to arginine and L Dopa
AU - Pontiroli, A. E.
AU - Viberti, G. C.
AU - Tognetti, A.
AU - Pozza, G.
PY - 1976
Y1 - 1976
N2 - In seven normal subjects the repeated oral administration of metergoline, a specific antiserotonin agent, has enhanced HGH response to arginine infusion. Following placebo administration, arginine induced HGH release was slightly but not significantly reduced; similarly, in eight metergoline treated subjects, HGH response to oral L Dopa was slightly but not significantly reduced. HGH response to i.v. L Dopa was not modified by the drug. These results suggest that serotonin controls HGH response only in response to arginine, not to L Dopa.
AB - In seven normal subjects the repeated oral administration of metergoline, a specific antiserotonin agent, has enhanced HGH response to arginine infusion. Following placebo administration, arginine induced HGH release was slightly but not significantly reduced; similarly, in eight metergoline treated subjects, HGH response to oral L Dopa was slightly but not significantly reduced. HGH response to i.v. L Dopa was not modified by the drug. These results suggest that serotonin controls HGH response only in response to arginine, not to L Dopa.
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M3 - Article
C2 - 1261961
AN - SCOPUS:0017283043
VL - 8
SP - 106
EP - 108
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 2
ER -