Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Vladimir N. Anisimov, Lev M. Berstein, Peter A. Egormin, Tatiana S. Piskunova, Irina G. Popovich, Mark A. Zabezhinski, Irina G. Kovalenko, Tatiana E. Poroshina, Anna V. Semenchenko, Mauro Provinciali, Francesca Re, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include DAF-2 and InR and their homologues in mammals, and inactivation of the corresponding genes is followed by increased life span in nematodes, fruit flies and mice. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which mimetic effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity. The chronic treatment of female transgenic HER-2/neu mice with metformin (100 mg/kg in drinking water) slightly decreased the food consumption but failed in reducing the body weight or temperature, slowed down the age-related rise in blood glucose and triglycerides level, as well as the age-related switch-off of estrous function, prolonged the mean life span by 8% (p

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalExperimental Gerontology
Volume40
Issue number8-9
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Biguanides
  • HER-2/neu
  • Mammary cancer
  • Transgenic mice

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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  • Cite this

    Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., Re, F., & Franceschi, C. (2005). Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Experimental Gerontology, 40(8-9), 685-693. https://doi.org/10.1016/j.exger.2005.07.007