Abstract
In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.
Original language | English |
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Pages (from-to) | 513-515 |
Number of pages | 3 |
Journal | European Journal of Clinical Pharmacology |
Volume | 34 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 1988 |
Keywords
- hypertension
- methyldopa
- prolactin
- sustained release formulation
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)