Effect of methyldopa on prolactin serum concentration - Comparison between normal and sustained-release formulations

M. Baldini; U. Cornelli; M. Molinari; L. Cantalamessa

doi:10.1007/BF01046712

Effect of methyldopa on prolactin serum concentration - Comparison between normal and sustained-release formulations

M. Baldini, U. Cornelli, M. Molinari, L. Cantalamessa

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.

Original language	English
Pages (from-to)	513-515
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/BF01046712
Publication status	Published - Sep 1988

Keywords

hypertension
methyldopa
prolactin
sustained release formulation

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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abstract = "In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.",

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AU - Baldini, M.

AU - Cornelli, U.

AU - Molinari, M.

AU - Cantalamessa, L.

PY - 1988/9

Y1 - 1988/9

N2 - In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.

AB - In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.

KW - hypertension

KW - methyldopa

KW - prolactin

KW - sustained release formulation

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JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

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Effect of methyldopa on prolactin serum concentration - Comparison between normal and sustained-release formulations

Abstract

Keywords

ASJC Scopus subject areas

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