Effect of methyldopa on prolactin serum concentration - Comparison between normal and sustained-release formulations

M. Baldini, U. Cornelli, M. Molinari, L. Cantalamessa

Research output: Contribution to journalArticlepeer-review

Abstract

In a group of ten hypertensive patients, the effects of methyldopa administration in two different formulations on serum prolactin (PRL) were studied. A single oral dose of normal release methyldopa significantly increased serum prolactin levels, peak concentrations occurring 3 to 6 h after drug administration. On the contrary, administration of sustained release methyldopa at the same dose was only followed by slight and not significant fluctuations in prolactin plasma levels. Both formulations produced a significant decrease of systolic and diastolic blood pressures, without significant differences between sustained and normal release methyldopa effects.

Original languageEnglish
Pages (from-to)513-515
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume34
Issue number5
DOIs
Publication statusPublished - Sep 1988

Keywords

  • hypertension
  • methyldopa
  • prolactin
  • sustained release formulation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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