Abstract
Growth hormone (GH) secretory response to metoclopramide (MCP) administration was evaluated in 9 male patients with liver cirrhosis and in 6 normal controls. As expected, MCP did not modify serum GH concentrations in normal subjects. In contrast, a striking GH secretory response to MCP was observed in 5 out of 9 cirrhotics. In the other four patients serum GH levels did not show any variation after MCP. The different behavior between cirrhotic “responders” and “non responders” can not be interpreted on the basis of the medical history or the clinical and laboratory data. Three hypothesis are proposed: i) The effect of MCP could be promoted by estrogens and inhibited by androgens. ii) False neurochemical transmitters could affect dopaminergic system of some cirrhotics, allowing or inhibiting the GH response to MCP. iii) MCP could stimulate GH secretion by a serotonergic mechanism. These findings provide further evidence of a modification of the GH secretory pattern in patients with cirrhosis of the liver.
| Original language | English |
|---|---|
| Pages (from-to) | 101-105 |
| Number of pages | 5 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1983 |
Fingerprint
Keywords
- 17-beta-estradiol
- GH
- liver cirrhosis
- Metoclopramide
- testosterone
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Effect of metoclopramide on serum growth hormone levels in cirrhotic men. / Volpi, R.; Coiro, V.; Salvi, M.; Pelosi, G.; Mancini, P.; Chiodera, P.
In: Journal of Endocrinological Investigation, Vol. 6, No. 2, 1983, p. 101-105.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of metoclopramide on serum growth hormone levels in cirrhotic men
AU - Volpi, R.
AU - Coiro, V.
AU - Salvi, M.
AU - Pelosi, G.
AU - Mancini, P.
AU - Chiodera, P.
PY - 1983
Y1 - 1983
N2 - Growth hormone (GH) secretory response to metoclopramide (MCP) administration was evaluated in 9 male patients with liver cirrhosis and in 6 normal controls. As expected, MCP did not modify serum GH concentrations in normal subjects. In contrast, a striking GH secretory response to MCP was observed in 5 out of 9 cirrhotics. In the other four patients serum GH levels did not show any variation after MCP. The different behavior between cirrhotic “responders” and “non responders” can not be interpreted on the basis of the medical history or the clinical and laboratory data. Three hypothesis are proposed: i) The effect of MCP could be promoted by estrogens and inhibited by androgens. ii) False neurochemical transmitters could affect dopaminergic system of some cirrhotics, allowing or inhibiting the GH response to MCP. iii) MCP could stimulate GH secretion by a serotonergic mechanism. These findings provide further evidence of a modification of the GH secretory pattern in patients with cirrhosis of the liver.
AB - Growth hormone (GH) secretory response to metoclopramide (MCP) administration was evaluated in 9 male patients with liver cirrhosis and in 6 normal controls. As expected, MCP did not modify serum GH concentrations in normal subjects. In contrast, a striking GH secretory response to MCP was observed in 5 out of 9 cirrhotics. In the other four patients serum GH levels did not show any variation after MCP. The different behavior between cirrhotic “responders” and “non responders” can not be interpreted on the basis of the medical history or the clinical and laboratory data. Three hypothesis are proposed: i) The effect of MCP could be promoted by estrogens and inhibited by androgens. ii) False neurochemical transmitters could affect dopaminergic system of some cirrhotics, allowing or inhibiting the GH response to MCP. iii) MCP could stimulate GH secretion by a serotonergic mechanism. These findings provide further evidence of a modification of the GH secretory pattern in patients with cirrhosis of the liver.
KW - 17-beta-estradiol
KW - GH
KW - liver cirrhosis
KW - Metoclopramide
KW - testosterone
UR - http://www.scopus.com/inward/record.url?scp=0020967420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020967420&partnerID=8YFLogxK
U2 - 10.1007/BF03350580
DO - 10.1007/BF03350580
M3 - Article
C2 - 6863846
AN - SCOPUS:0020967420
VL - 6
SP - 101
EP - 105
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 2
ER -