Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times

G. La Colla, L. La Colla, S. Turi, D. Poli, A. Albertin, N. Pasculli, Pier Carlo Bergonzi, M. Gonfalini, F. Ruggieri

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim. The aim of this paper was to compare wash-in and wash-out curves of desflurane in morbidly obese and nonobese patients. Methods. Fourteen patients (7 obese and 7 nonobese) were studied. In the nonobese patients, anaesthesia was started by administering 2 mg/kg propofol bolus and a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. Obese patients were intubated using a flexible fiberoptic bronchoscopic technique facilitated by a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. After endotracheal intubation, general anaesthesia was started by administering a 1.5 mg/kg propofol bolus dose. Ten minutes after induction of anaesthesia, 4% desflurane was administered for 30 min. Desflurane kinetics was determined by collecting end-tidal samples from first breaths at 1, 5, 10, 15, 20, 25 and 30 min. At last skin suture, the end-tidal concentration of desflurane was recorded from 5 consecutive breaths before their discontinuation, then the end-tidal samples of the inhalational agent were collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5 min after terminating its administration. The period of time from discontinuation of desflurane to opening eyes, squeezing the observer's hand, extubation, stating the patients' name and providing date of birth was also recorded. Results. The FA/FI ratio was higher in the nonobese group from the 10th to the 15th min. Wash-out curves of desflurane and recovery times were similar. Conclusion. Our results show that desflurane provides similar kinetic and recovery profiles in obese and nonobese patients.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalMinerva Anestesiologica
Volume73
Issue number5
Publication statusPublished - May 2007

Fingerprint

Morbid Obesity
Propofol
Anesthesia
Intratracheal Intubation
desflurane
General Anesthesia
Sutures
Names
Hand
Parturition
Skin

Keywords

  • Desflurane
  • Kinetics
  • Obesity
  • Remifentanil

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

La Colla, G., La Colla, L., Turi, S., Poli, D., Albertin, A., Pasculli, N., ... Ruggieri, F. (2007). Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times. Minerva Anestesiologica, 73(5), 275-279.

Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times. / La Colla, G.; La Colla, L.; Turi, S.; Poli, D.; Albertin, A.; Pasculli, N.; Bergonzi, Pier Carlo; Gonfalini, M.; Ruggieri, F.

In: Minerva Anestesiologica, Vol. 73, No. 5, 05.2007, p. 275-279.

Research output: Contribution to journalArticle

La Colla, G, La Colla, L, Turi, S, Poli, D, Albertin, A, Pasculli, N, Bergonzi, PC, Gonfalini, M & Ruggieri, F 2007, 'Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times', Minerva Anestesiologica, vol. 73, no. 5, pp. 275-279.
La Colla G, La Colla L, Turi S, Poli D, Albertin A, Pasculli N et al. Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times. Minerva Anestesiologica. 2007 May;73(5):275-279.
La Colla, G. ; La Colla, L. ; Turi, S. ; Poli, D. ; Albertin, A. ; Pasculli, N. ; Bergonzi, Pier Carlo ; Gonfalini, M. ; Ruggieri, F. / Effect of morbid obesity on kinetic of desflurane wash-in wash-out curves and recovery times. In: Minerva Anestesiologica. 2007 ; Vol. 73, No. 5. pp. 275-279.
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abstract = "Aim. The aim of this paper was to compare wash-in and wash-out curves of desflurane in morbidly obese and nonobese patients. Methods. Fourteen patients (7 obese and 7 nonobese) were studied. In the nonobese patients, anaesthesia was started by administering 2 mg/kg propofol bolus and a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. Obese patients were intubated using a flexible fiberoptic bronchoscopic technique facilitated by a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. After endotracheal intubation, general anaesthesia was started by administering a 1.5 mg/kg propofol bolus dose. Ten minutes after induction of anaesthesia, 4{\%} desflurane was administered for 30 min. Desflurane kinetics was determined by collecting end-tidal samples from first breaths at 1, 5, 10, 15, 20, 25 and 30 min. At last skin suture, the end-tidal concentration of desflurane was recorded from 5 consecutive breaths before their discontinuation, then the end-tidal samples of the inhalational agent were collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5 min after terminating its administration. The period of time from discontinuation of desflurane to opening eyes, squeezing the observer's hand, extubation, stating the patients' name and providing date of birth was also recorded. Results. The FA/FI ratio was higher in the nonobese group from the 10th to the 15th min. Wash-out curves of desflurane and recovery times were similar. Conclusion. Our results show that desflurane provides similar kinetic and recovery profiles in obese and nonobese patients.",
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AU - La Colla, G.

AU - La Colla, L.

AU - Turi, S.

AU - Poli, D.

AU - Albertin, A.

AU - Pasculli, N.

AU - Bergonzi, Pier Carlo

AU - Gonfalini, M.

AU - Ruggieri, F.

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AB - Aim. The aim of this paper was to compare wash-in and wash-out curves of desflurane in morbidly obese and nonobese patients. Methods. Fourteen patients (7 obese and 7 nonobese) were studied. In the nonobese patients, anaesthesia was started by administering 2 mg/kg propofol bolus and a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. Obese patients were intubated using a flexible fiberoptic bronchoscopic technique facilitated by a target controlled effect site concentration of remifentanil set at 2.5 ng/mL. After endotracheal intubation, general anaesthesia was started by administering a 1.5 mg/kg propofol bolus dose. Ten minutes after induction of anaesthesia, 4% desflurane was administered for 30 min. Desflurane kinetics was determined by collecting end-tidal samples from first breaths at 1, 5, 10, 15, 20, 25 and 30 min. At last skin suture, the end-tidal concentration of desflurane was recorded from 5 consecutive breaths before their discontinuation, then the end-tidal samples of the inhalational agent were collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 and 5 min after terminating its administration. The period of time from discontinuation of desflurane to opening eyes, squeezing the observer's hand, extubation, stating the patients' name and providing date of birth was also recorded. Results. The FA/FI ratio was higher in the nonobese group from the 10th to the 15th min. Wash-out curves of desflurane and recovery times were similar. Conclusion. Our results show that desflurane provides similar kinetic and recovery profiles in obese and nonobese patients.

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