TY - JOUR
T1 - Effect of multiple herpesvirus infections on the progression of HIV disease in a Cohort of HIV seroconverters
AU - Suligoi, Barbara
AU - Dorrucci, Maria
AU - Uccella, Ilaria
AU - Andreoni, Massimo
AU - Rezza, Giovanni
AU - Pezzotti, Patrizio
AU - Sinicco, Alessandro
AU - Zerboni, Roberto
AU - Lazzarin, Adriano
AU - Aiuti, Fernando
AU - Zaccarelli, Mauro
AU - Salassa, Bernardino
AU - Castelli, Francesco
AU - Alberici, Francesco
AU - Mazzarello, Giovanni
AU - Barbanera, Mauro
AU - Colangeli, Vincenzo
AU - Ortona, Luigi
AU - Pristerà, Raffaele
AU - Ursitti, Maria A.
AU - Tirelli, Umberto
AU - Giuliani, Massimo
PY - 2003/2/1
Y1 - 2003/2/1
N2 - The effects of herpesviruses infection on the progression of HIV disease remain controversial, with some studies showing accelerated progression and others showing no effect. Furthermore, the effect of concurrent infection with more than one herpesvirus on the progression of HIV disease has never been investigated. To this end, the rates of progression of HIV disease were determined after stratifying for the presence of up to five different herpesvirus infections. The study population consisted of 359 HIV-infected persons for whom the date of seroconversion was estimated (part of the Italian Seroconversion Study). One serum sample from each participant was tested for antibodies to five herpesviruses: HSV-2, CMV, HHV-6, HHV-7, and HHV-8. Univariate analysis showed that HSV-2 and HHV-8 were significantly associated with progression to AIDS, yet when adjusting for age at HIV seroconversion and for the presence of the other herpesvirus infections, only HHV-8 infection showed a significant association. The age-adjusted risk of progression to AIDS with Kaposi's sarcoma increased with the number of herpesvirus infections and was significant in individuals with four infections. The risk of progression to AIDS without Kaposi's sarcoma also increased with the number of infections, although not significantly. Similar results were found when considering CD4+ cell count 6 cells/L as the endpoint. Concurrent infection with more than one herpesvirus does not appear to have a significant effect on the course of HIV disease, except for the known association between HHV-8 and Kaposi's sarcoma. However, even after excluding Kaposi's sarcoma from the AIDS-defining endpoints, a slightly increased risk for participants with four herpesvirus infections remained.
AB - The effects of herpesviruses infection on the progression of HIV disease remain controversial, with some studies showing accelerated progression and others showing no effect. Furthermore, the effect of concurrent infection with more than one herpesvirus on the progression of HIV disease has never been investigated. To this end, the rates of progression of HIV disease were determined after stratifying for the presence of up to five different herpesvirus infections. The study population consisted of 359 HIV-infected persons for whom the date of seroconversion was estimated (part of the Italian Seroconversion Study). One serum sample from each participant was tested for antibodies to five herpesviruses: HSV-2, CMV, HHV-6, HHV-7, and HHV-8. Univariate analysis showed that HSV-2 and HHV-8 were significantly associated with progression to AIDS, yet when adjusting for age at HIV seroconversion and for the presence of the other herpesvirus infections, only HHV-8 infection showed a significant association. The age-adjusted risk of progression to AIDS with Kaposi's sarcoma increased with the number of herpesvirus infections and was significant in individuals with four infections. The risk of progression to AIDS without Kaposi's sarcoma also increased with the number of infections, although not significantly. Similar results were found when considering CD4+ cell count 6 cells/L as the endpoint. Concurrent infection with more than one herpesvirus does not appear to have a significant effect on the course of HIV disease, except for the known association between HHV-8 and Kaposi's sarcoma. However, even after excluding Kaposi's sarcoma from the AIDS-defining endpoints, a slightly increased risk for participants with four herpesvirus infections remained.
KW - AIDS
KW - Cohort study
KW - Epidemiology
KW - Herpesviruses
KW - HIV
UR - http://www.scopus.com/inward/record.url?scp=12244278342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12244278342&partnerID=8YFLogxK
U2 - 10.1002/jmv.10281
DO - 10.1002/jmv.10281
M3 - Article
C2 - 12683405
AN - SCOPUS:12244278342
VL - 69
SP - 182
EP - 187
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 2
ER -