Effect of myofibril architecture on the active contraction of dystrophic muscle. A mathematical model

Marco Stefanati, Yvan Torrente, José Félix Rodriguez Matas

Research output: Contribution to journalArticlepeer-review

Abstract

Duchenne muscular dystrophy (DMD) is a muscle degenerative disease caused by a mutation in the dystrophin gene. The lack of dystrophin leads to persistent inflammation, degeneration/regeneration cycles of muscle fibers, Ca2+ dysregulation, incompletely regenerated fibers, necrosis, fibrotic tissue replacement, and alterations in the fiber ultrastructure i.e., myofibril misalignment and branched fibers. This work aims to develop a comprehensive chemo-mechanical model of muscle-skeletal tissue accounting for dispersion in myofibrillar orientations, in addition to the disorders in sarcomere pattern and the fiber branching. The model results confirm a significant correlation between the myofibrillar dispersion and the reduction of isometric force in the dystrophic muscle and indicate that the reduction of contraction velocity in the dystrophic muscle seems to be associated with the local disorders in the sarcomere patterns of the myofibrils. Also, the implemented model can predict the force–velocity response to both concentric and eccentric loading. The resulting model represents an original approach to account for defects in the muscle ultrastructure caused by pathologies as DMD.

Original languageEnglish
Article number104214
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume114
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Dystrophic skeletal muscle model
  • Fibril misalignment effect
  • Skeletal muscle model

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'Effect of myofibril architecture on the active contraction of dystrophic muscle. A mathematical model'. Together they form a unique fingerprint.

Cite this