Effect of naloxone on oxytocin-induced cortisol decrease in normal men

V. Coiro, P. Chiodera, G. Rossi, R. Volpi, M. Salvi, L. Camellini, E. Roti

Research output: Contribution to journalArticle

Abstract

Iv administration of oxytocin decreases plasma ACTH-cortisol levels in normal men. In contrast, naloxone, a specific opioid antagonist, stimulates cortisol release, suggesting that opioid peptides exert an inhibitory control on ACTH-cortisol secretion. The present study was carried out in an attempt to determine whether an opioid pathway mediates oxytocin action; therefore, we evaluated the effect of naloxone on the decrease of cortisol induced by oxytocin. Six normal men were treated iv with oxytocin (2 IU as a bolus), naloxone (4 mg as a bolus plus 10 mg infused for 2 h) or a combination of the 2 drugs. Plasma cortisol levels were determined in samples taken before and 2 h after drug treatment. As expected, administration of oxytocin significantly decreased cortisol secretion, while naloxone had a stimulatory effect on plasma cortisol levels. When oxytocin injection was followed by administration of naloxone, cortisol levels remained unchanged; thus, naloxone abolished a cortisol decrement in response to oxytocin. These findings show that in man oxytocin requires an active opioid system in order to produce its inhibitory action on ACTH-cortisol secretion, suggesting that this effect of oxytocin could be mediated by an opioid pathway.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalActa Endocrinologica
Volume108
Issue number2
Publication statusPublished - 1985

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Oxytocin
Naloxone
Hydrocortisone
Adrenocorticotropic Hormone
Opioid Analgesics
Opioid Peptides
Narcotic Antagonists
Drug Combinations
Injections

ASJC Scopus subject areas

  • Endocrinology

Cite this

Coiro, V., Chiodera, P., Rossi, G., Volpi, R., Salvi, M., Camellini, L., & Roti, E. (1985). Effect of naloxone on oxytocin-induced cortisol decrease in normal men. Acta Endocrinologica, 108(2), 261-265.

Effect of naloxone on oxytocin-induced cortisol decrease in normal men. / Coiro, V.; Chiodera, P.; Rossi, G.; Volpi, R.; Salvi, M.; Camellini, L.; Roti, E.

In: Acta Endocrinologica, Vol. 108, No. 2, 1985, p. 261-265.

Research output: Contribution to journalArticle

Coiro, V, Chiodera, P, Rossi, G, Volpi, R, Salvi, M, Camellini, L & Roti, E 1985, 'Effect of naloxone on oxytocin-induced cortisol decrease in normal men', Acta Endocrinologica, vol. 108, no. 2, pp. 261-265.
Coiro V, Chiodera P, Rossi G, Volpi R, Salvi M, Camellini L et al. Effect of naloxone on oxytocin-induced cortisol decrease in normal men. Acta Endocrinologica. 1985;108(2):261-265.
Coiro, V. ; Chiodera, P. ; Rossi, G. ; Volpi, R. ; Salvi, M. ; Camellini, L. ; Roti, E. / Effect of naloxone on oxytocin-induced cortisol decrease in normal men. In: Acta Endocrinologica. 1985 ; Vol. 108, No. 2. pp. 261-265.
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