Effect of naloxone on prolactin response to surgical stress

L. Stella, A. Crescenti, A. E. Pontiroli

Research output: Contribution to journalArticlepeer-review


The effect of naloxone on prolactin response to surgical stress has been studied in 24 patients of both sexes undergoing surgical procedure for gallstones. Patients were selected and distributed at random in two groups of equal size; the first group received 6 μg/kg i.v. of naloxone before induction, the second an equal volume of isotonic saline solution. In all patients induction and maintenance of anaesthesia was assured utilizing the same technique. Prolactin serum levels were evaluated one day before operation, 10 minutes before induction, 10 minutes after induction and then every 15 minutes. Skin incision was made 20 minutes after induction in all patients. Prolactin concentrations were statistically analysed separately in females and males. In the control group an important rise in prolactin concentration was evident after skin incision both in females and males; in the naloxone treated group this response was significantly reduced. During the whole operative period prolactin concentrations were statistically lower in the naloxone treated group than in control. These results suggest that opioid peptides are involved in prolactin release induced by surgical stress and that naloxone administration partially blocks this hormonal response.

Original languageEnglish
Pages (from-to)732
Number of pages1
JournalIRCS Medical Science
Issue number8
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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