Effect of naltrexone treatment on the treadmill exercise-induced hormone release in amenorrheic women

G. Botticelli, A. Bacchi Modena, D. Bresciani, P. Villa, L. Aguzzoli, P. Florio, R. E. Nappi, Felice Petraglia, A. R. Genazzani

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Abstract

The effect of an acute physical stress on hormone secretions before and after a 10-day naltrexone treatment in untrained healthy and amenorrheic women was investigated. Plasma levels of pituitary (LH, FSH, prolactin, GH, ACTH, gB-endor-phin) and adrenal (Cortisol, androstenedione, testosterone) hormones were measured at rest and in response to 60 min of physical exercise. The test was done both before and after a 10-day naltrexone (50 mg/day) treatment. Graded levels of treadmill exercise (50, 70 and 90% of maximal oxygen uptake (V02) every 20 min) was used as physical stressor. While mean ± SE plasma LH levels in control women were higher than in amenorrheic patients and increased following the naltrexone treatment (p

Original languageEnglish
Pages (from-to)839-847
Number of pages9
JournalJournal of Endocrinological Investigation
Volume15
Issue number11
DOIs
Publication statusPublished - 1992

Keywords

  • adrenal steroids
  • beta-endorphin
  • growth hormone
  • hypothalamic amenorrhea
  • naltrexone
  • Physical exercise
  • prolactin
  • stress

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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