Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers

M. Di Gioacchino, E. Cavallucci, F. Di Stefano, F. Paolini, S. Ramondo, M. B. Di Sciascio, S. Ciuffreda, G. Riccioni, R. Della Vecchia, A. Romano, P. Boscolo

Research output: Contribution to journalArticle

Abstract

The aim of the study was to assess the seasonal variability of non-specific bronchial reactivity (NSBR) evaluated with methacholine in asthmatic farmers allergic to pollens. Twenty farmers (16 male and four female) with allergy to pollens, e.g. 'Graminae' and 'Parietaria', entered the study. None of the patients had been previously treated with specific immunotherapy. Patients underwent a methacholine challenge at the first visit and then in the subsequent seasons. Four groups of tests were obtained according to the period when the challenge was performed. Group 1: challenges performed in December, January and February; group 2 in March, April and May; group 3 in June, July and August; group 4 in September, October and November. PD20 values were expressed as the natural logarithm of the cumulative dose of methacholine causing at least a 20% fall in FEV1. Bronchial hyperreactivity was highest in summer, followed by spring and autumn; in winter it was much lower. Multiple group analysis (ANOVA) showed statistically significant differences between the groups (P

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalScience of the Total Environment
Volume270
Issue number1-3
DOIs
Publication statusPublished - Apr 10 2001

Fingerprint

Allergens
Allergies
Methacholine Chloride
Analysis of variance (ANOVA)
pollen
allergy
autumn
winter
summer
allergen
effect
exposure
test
dose
analysis

Keywords

  • Allergy
  • Farmers
  • Graminae pollen
  • Non-specific bronchial reactivity
  • Parietaria pollen

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Di Gioacchino, M., Cavallucci, E., Di Stefano, F., Paolini, F., Ramondo, S., Di Sciascio, M. B., ... Boscolo, P. (2001). Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers. Science of the Total Environment, 270(1-3), 43-48. https://doi.org/10.1016/S0048-9697(00)00799-3

Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers. / Di Gioacchino, M.; Cavallucci, E.; Di Stefano, F.; Paolini, F.; Ramondo, S.; Di Sciascio, M. B.; Ciuffreda, S.; Riccioni, G.; Della Vecchia, R.; Romano, A.; Boscolo, P.

In: Science of the Total Environment, Vol. 270, No. 1-3, 10.04.2001, p. 43-48.

Research output: Contribution to journalArticle

Di Gioacchino, M, Cavallucci, E, Di Stefano, F, Paolini, F, Ramondo, S, Di Sciascio, MB, Ciuffreda, S, Riccioni, G, Della Vecchia, R, Romano, A & Boscolo, P 2001, 'Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers', Science of the Total Environment, vol. 270, no. 1-3, pp. 43-48. https://doi.org/10.1016/S0048-9697(00)00799-3
Di Gioacchino M, Cavallucci E, Di Stefano F, Paolini F, Ramondo S, Di Sciascio MB et al. Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers. Science of the Total Environment. 2001 Apr 10;270(1-3):43-48. https://doi.org/10.1016/S0048-9697(00)00799-3
Di Gioacchino, M. ; Cavallucci, E. ; Di Stefano, F. ; Paolini, F. ; Ramondo, S. ; Di Sciascio, M. B. ; Ciuffreda, S. ; Riccioni, G. ; Della Vecchia, R. ; Romano, A. ; Boscolo, P. / Effect of natural allergen exposure on non-specific bronchial reactivity in asthmatic farmers. In: Science of the Total Environment. 2001 ; Vol. 270, No. 1-3. pp. 43-48.
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