Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice

L. Aloe; A. Micera; P. Tirassa; L. Probert; G. Kollias

doi:10.1007/BF00262091

Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice

L. Aloe, A. Micera, P. Tirassa, L. Probert, G. Kollias

Fondazione G.B. Bietti

Research output: Contribution to journal › Article › peer-review

Abstract

We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.

Original language	English
Pages (from-to)	249-252
Number of pages	4
Journal	Rheumatology International
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/BF00262091
Publication status	Published - Mar 1995

Keywords

Mast cells
Nerve growth factor NGF antibodies
Transgenic mouse
Tumour necrosis factor

ASJC Scopus subject areas

Rheumatology

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10.1007/BF00262091

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abstract = "We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.",

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AU - Aloe, L.

AU - Micera, A.

AU - Tirassa, P.

AU - Probert, L.

AU - Kollias, G.

PY - 1995/3

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AB - We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.

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KW - Nerve growth factor NGF antibodies

KW - Transgenic mouse

KW - Tumour necrosis factor

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Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice

Abstract

Keywords

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