Abstract
We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | Rheumatology International |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 1995 |
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Keywords
- Mast cells
- Nerve growth factor NGF antibodies
- Transgenic mouse
- Tumour necrosis factor
ASJC Scopus subject areas
- Rheumatology
Cite this
Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice. / Aloe, L.; Micera, A.; Tirassa, P.; Probert, L.; Kollias, G.
In: Rheumatology International, Vol. 14, No. 6, 03.1995, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice
AU - Aloe, L.
AU - Micera, A.
AU - Tirassa, P.
AU - Probert, L.
AU - Kollias, G.
PY - 1995/3
Y1 - 1995/3
N2 - We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.
AB - We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.
KW - Mast cells
KW - Nerve growth factor NGF antibodies
KW - Transgenic mouse
KW - Tumour necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=0028923211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028923211&partnerID=8YFLogxK
U2 - 10.1007/BF00262091
DO - 10.1007/BF00262091
M3 - Article
VL - 14
SP - 249
EP - 252
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 6
ER -