Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice

L. Aloe, A. Micera, P. Tirassa, L. Probert, G. Kollias

Research output: Contribution to journalArticle

Abstract

We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalRheumatology International
Volume14
Issue number6
DOIs
Publication statusPublished - Mar 1995

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Keywords

  • Mast cells
  • Nerve growth factor NGF antibodies
  • Transgenic mouse
  • Tumour necrosis factor

ASJC Scopus subject areas

  • Rheumatology

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