Effect of nifedipine and verapamil on carbohydrate metabolism in hypertensive patients with impaired glucose tolerance

Paolo Dessì-Fulgheri, Adolfo Pacifico, Francesco Bandiera, Speranza Rubattu, Paolo Madeddu, Nicola Glorioso, Mario Maioli, Giuseppe Delitala, Paolo Tomasi, Alessandro Rappelli

Research output: Contribution to journalArticle

Abstract

Intracellular Ca2+ influx is an essential step in insulin (I) release. Calcium antagonists are reported to reduce I release in vitro and in patients with impaired glucose tolerance (IGT) during acute administration. Their effects during long-term therapy are still controversial. To evaluate the effects of chronic verapamil (V) and nifedipine (N) on carbohydrate metabolism, 12 hypertensive patients (WHO II; aged 37-64 years) with IGT underwent intravenous glucose tolerance tests (IVGTT) (0.33 g/kg body weight in 3 min), arginine (A) infusion (30 g/30 min), and hypoglycemic stress (regular insulin 0.15 U/kg body weight) during which blood levels of glucose (G), I, growth hormone (GH), glucagon (IRG), and cortisol (C) were measured. The patients were then randomized to V (120 mg b.i.d.) or N (20 mg b.i.d.) treatment and, 1 month later, both IVGTT and A infusion were repeated. Hormone determinations were performed by the radioimmunoassay (RIA) and G by the enzymatic method. The patients were maintained on their usual diet for the duration of the study. The rate of decline of G during IVGTT was expressed as Conard's K coefficient (K; normal values > 1.3). I and GH during IVGTT were evaluated as the differences between basal and peak values. I, IRG, and GH during A infusion were analyzed as incremental areas. Our results show that neither V nor N impaired carbohydrate metabolism in hypertensive patients with IGT.

Original languageEnglish
Pages (from-to)S195-S198
JournalJournal of Cardiovascular Pharmacology
Volume10
Publication statusPublished - 1987

Keywords

  • Calcium entry blockers
  • Glucose tolerance
  • Nifedipine
  • Verapamil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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    Dessì-Fulgheri, P., Pacifico, A., Bandiera, F., Rubattu, S., Madeddu, P., Glorioso, N., Maioli, M., Delitala, G., Tomasi, P., & Rappelli, A. (1987). Effect of nifedipine and verapamil on carbohydrate metabolism in hypertensive patients with impaired glucose tolerance. Journal of Cardiovascular Pharmacology, 10, S195-S198.