Effect of nitrendipine on histamine release from human basophil leukocytes

A. Miadonna, A. Tedeschi, E. Leggieri, C. Fabbri, M. Lorini, M. Froldi, C. Zanussi

Research output: Contribution to journalArticle

Abstract

The effect of the new calcium antagonist nitrendipine on in vitro basophil activation was evaluated in 10 subjects. The histamine release induced by calcium ionophore A23187, f-met peptide and anti-IgE was inhibited, in a dose-dependent fashion, by nitrendipine in the concentration range of 1-100 μM. The activity of this calcium antagonist seems complex and related to an interference with calcium at multiple sites. At concentrations higher than 200 μM, nitrendipine causes histamine release from basophil leukocytes. This histamine secretion is likely to be due to a cytotoxic effect, since it is associated with an increase in LDH levels in the cell supernatant.

Original languageEnglish
Pages (from-to)298-304
Number of pages7
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume42
Issue number4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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    Miadonna, A., Tedeschi, A., Leggieri, E., Fabbri, C., Lorini, M., Froldi, M., & Zanussi, C. (1987). Effect of nitrendipine on histamine release from human basophil leukocytes. Allergy: European Journal of Allergy and Clinical Immunology, 42(4), 298-304.