Effect of nitrous oxide on desflurane MACBAR at two target-controlled concentrations of remifentanil

E. Dedola, A. Albertin, D. Poli, L. La Colla, A. Gandolfi, C. Martani, G. Torri

Research output: Contribution to journalArticlepeer-review


Background. The aim of this prospective, randomized, double-blind study was to determine the effect of nitrous oxide on the desflurane requirement for blunting sympathetic response following surgical incision (MACBAR) when desflurane was combined with two different target-controlled concentrations of remifentanil (1 and 3 ng/mL). Methods. A total of 103 patients, aged 20-50 years, ASA physical status I, scheduled to undergo general anesthesia for elective abdominal surgery, were randomly allocated to receive anesthesia with desflurane alone (Group A, n = 53), or with the addition of 60% nitrous oxide (Group N, n = 50). Patients of both groups were further assigned to receive a target-controlled plasma concentration of 1 ng/mL (Group A1, n = 27; Group N1, n = 26) or 3 ng/mL remifentanil (Group A3, n = 26, Group N3, n = 24). Sympathetic responses to surgical incision were determined after a 20 min period of constant end-tidal desflurane and target-controlled remifentanil concentrations. Predetermined end-tidal desflurane concentrations and the MACBAR for each group were determined using an up-and-down sequential allocation technique. Results. A total of 98 patients completed the study. The MACBAR of desflurane was 5.2% (95% confidence interval [C195: 4.9-5.5%]) in Group A1 and 2.7% (C195: 2.6-2.8%) in Group N1 (P

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalMinerva Anestesiologica
Issue number5
Publication statusPublished - May 2008


  • Desflurane
  • Nitric oxide
  • Remifentanil
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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