Effect of nomifensine on acetylcholine and choline in the rat striatum and brainstem

Silvio Garattini, Silvana Consolo, Giuseppe Chittò, Giuseppe Peri, Herbert Ladinsky

Research output: Contribution to journalArticlepeer-review

Abstract

Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipramine both produced a small but significant increase in brainstem acetylcholine. It is suggested that nomifensine increased striatal acetylcholine indirectly through blockade of dopamine uptake.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalEuropean Journal of Pharmacology
Volume35
Issue number1
DOIs
Publication statusPublished - 1976

Keywords

  • Acetylcholine
  • Brainstem
  • Choline
  • d-Amphetamine
  • Desipramine
  • Nomifensine
  • Rat striatum

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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