Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients

Filomena Addante; Daniele Sancarlo; Massimiliano Copetti; Carlo Scarcelli; Maria Grazia Longo; Valeria Niro; Giulia Paroni; Fabio Pellegrini; Luigi Fontana; Alberto Pilotto

doi:10.1089/rej.2010.1058

Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients

Filomena Addante, Daniele Sancarlo, Massimiliano Copetti, Carlo Scarcelli, Maria Grazia Longo, Valeria Niro, Giulia Paroni, Fabio Pellegrini, Luigi Fontana, Alberto Pilotto

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The aim of this study was to investigate the relationship among apolipoprotein E (APOE) polymorphism, body mass index (BMI), and dyslipidemia and how these factors modify overall mortality in a cohort of hospitalized elderly patients. Methods: Plasma concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), BMI, and APOE genotype were evaluated in 1,012 hospitalized elderly patients, who were stratified into three groups according to their baseline BMI and APOE allele status. Multivariate logistic regression analysis was used to assess whether APOE genotype, BMI, and dyslipidemia are associated with mortality, adjusting for potential confounders. Interaction analysis was also performed. Results: Obese patients have significantly higher levels of TC and LDL-C compared to normal-weight and overweight subjects, for both sexes. APOE ε4 carriers have significantly higher levels of TC and LDL-C compared with ε2 and ε3 carrier both in males and females. Interaction analysis showed that women with TC

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Rejuvenation Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1089/rej.2010.1058
Publication status	Published - Apr 1 2011

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

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Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients. / Addante, Filomena; Sancarlo, Daniele ; Copetti, Massimiliano; Scarcelli, Carlo; Longo, Maria Grazia; Niro, Valeria; Paroni, Giulia; Pellegrini, Fabio; Fontana, Luigi; Pilotto, Alberto.

In: Rejuvenation Research, Vol. 14, No. 2, 01.04.2011, p. 111-118.

Research output: Contribution to journal › Article › peer-review

Addante, Filomena ; Sancarlo, Daniele ; Copetti, Massimiliano ; Scarcelli, Carlo ; Longo, Maria Grazia ; Niro, Valeria ; Paroni, Giulia ; Pellegrini, Fabio ; Fontana, Luigi ; Pilotto, Alberto. / Effect of obesity, serum lipoproteins, and apolipoprotein e genotypes on mortality in hospitalized elderly patients. In: Rejuvenation Research. 2011 ; Vol. 14, No. 2. pp. 111-118.

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abstract = "Background: The aim of this study was to investigate the relationship among apolipoprotein E (APOE) polymorphism, body mass index (BMI), and dyslipidemia and how these factors modify overall mortality in a cohort of hospitalized elderly patients. Methods: Plasma concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), BMI, and APOE genotype were evaluated in 1,012 hospitalized elderly patients, who were stratified into three groups according to their baseline BMI and APOE allele status. Multivariate logistic regression analysis was used to assess whether APOE genotype, BMI, and dyslipidemia are associated with mortality, adjusting for potential confounders. Interaction analysis was also performed. Results: Obese patients have significantly higher levels of TC and LDL-C compared to normal-weight and overweight subjects, for both sexes. APOE ε4 carriers have significantly higher levels of TC and LDL-C compared with ε2 and ε3 carrier both in males and females. Interaction analysis showed that women with TC ",

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AU - Longo, Maria Grazia

AU - Niro, Valeria

AU - Paroni, Giulia

AU - Pellegrini, Fabio

AU - Fontana, Luigi

AU - Pilotto, Alberto

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