Effect of octreotide on neuroenolase levels in patients with small cell lung cancer

E. Soresi, G. Invernizzi, R. Boffi, U. Borghini, G. Schiraldi, P. V. Mantellini, G. Gramegna, A. Liuzzi

Research output: Contribution to journalArticle

Abstract

Aims and background: The somatostatin analog octreotide has an antiproliferative effect on small cell lung cancer lines in vitro and in experimental xenograft transplantation systems in vivo. Thus it is worth investigating octreotide activity in the clinical setting. Methods: We studied the effect of octreotide (200 μg three times a day subcutaneously for seven days) on serum levels of the tumor marker neuroenolase in 13 patients with small cell lung cancer. Results: A decrease in neuroenolase levels was observed at day 7 during octreotide treatment, with a mean ± SD of 32.6 ± 42.0 ng/ml compared to basal values of 44.4 ± 57.7 ng/ml and to washout values of 50.3 ± 65.7 ng/ml (R

Original languageEnglish
Pages (from-to)332-334
Number of pages3
JournalTumori
Volume80
Issue number5
Publication statusPublished - 1994

Keywords

  • neuron-specific enolase
  • octreotide
  • small cell lung cancer
  • somatostatin

ASJC Scopus subject areas

  • Cancer Research

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    Soresi, E., Invernizzi, G., Boffi, R., Borghini, U., Schiraldi, G., Mantellini, P. V., Gramegna, G., & Liuzzi, A. (1994). Effect of octreotide on neuroenolase levels in patients with small cell lung cancer. Tumori, 80(5), 332-334.