Abstract
Vaginal promestriene was tested in gynecological cancer patients who suffered from severe vaginal dryness and dyspareunia. This form of estrogen has a low level of vaginal absorption and proved to be effective for vaginal atrophy. Method: 17 patients were treated with a 10 mg soft vaginal suppository daily for one month. Plasma levels of estrone sulfate (E1S), used as the marker of overall estrogenicity, were measured by liquid chromatography in combination with mass spectrometry. Results: Mean E1S levels changed from 533 (22-2920) to 374 (81-856) pg/ml (p = 0.39). Conclusion: In highly symptomatic gynecological cancer patients the level of circulating estrone sulfate was not significantly affected by vaginal promestriene treatment overall, but a wide range of levels was noted pre and post treatment in individual patients.
Original language | English |
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Pages (from-to) | 93-94 |
Number of pages | 2 |
Journal | Maturitas |
Volume | 72 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 2012 |
Keywords
- Dyspareunia
- Estrone sulphate
- Female cancer patients
- Promestriene
- Vaginal dryness
- Vaginal estrogens
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Biochemistry, Genetics and Molecular Biology(all)