Effect of oral monosodium glutamate on glutamic acid levels in the nucleus arcuatus of the hypothalamus and on serum osmolality of adult and infant mice

L. Airoldi, M. Bonfanti, P. Ghezzi, M. Salmona, S. Garattini

Research output: Contribution to journalArticle

Abstract

Monosidum glutamate (MSG) given by gavage to 7-day-old mice at 2 g/kg body weight (b.wt.) as a 20% solution w/v resulted in a 27% increase in the glutamic acid (GA) content in the nucleus arcuatus of the hypothalamus (NAH). When MSG was administered by gavage to adult mice at 4 g/kg b.wt. as a 20% solution w/v, GA levels in NAH remained unchanged. Serum osmolality, measured after oral MSG, was elevated in infant mice but was unaffected in adults.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalToxicology Letters
Volume7
Issue number2
DOIs
Publication statusPublished - 1980

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Sodium Glutamate
Osmolar Concentration
Hypothalamus
Glutamic Acid
Serum
Body Weight

ASJC Scopus subject areas

  • Toxicology

Cite this

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abstract = "Monosidum glutamate (MSG) given by gavage to 7-day-old mice at 2 g/kg body weight (b.wt.) as a 20{\%} solution w/v resulted in a 27{\%} increase in the glutamic acid (GA) content in the nucleus arcuatus of the hypothalamus (NAH). When MSG was administered by gavage to adult mice at 4 g/kg b.wt. as a 20{\%} solution w/v, GA levels in NAH remained unchanged. Serum osmolality, measured after oral MSG, was elevated in infant mice but was unaffected in adults.",
author = "L. Airoldi and M. Bonfanti and P. Ghezzi and M. Salmona and S. Garattini",
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AU - Airoldi, L.

AU - Bonfanti, M.

AU - Ghezzi, P.

AU - Salmona, M.

AU - Garattini, S.

PY - 1980

Y1 - 1980

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AB - Monosidum glutamate (MSG) given by gavage to 7-day-old mice at 2 g/kg body weight (b.wt.) as a 20% solution w/v resulted in a 27% increase in the glutamic acid (GA) content in the nucleus arcuatus of the hypothalamus (NAH). When MSG was administered by gavage to adult mice at 4 g/kg b.wt. as a 20% solution w/v, GA levels in NAH remained unchanged. Serum osmolality, measured after oral MSG, was elevated in infant mice but was unaffected in adults.

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