Effect of osteoblast supernatants on cancer cell migration and invasion

Daniela Giunciuglio, Tania Cai, Cristina Filanti, Paola Manduca, Adriana Albini

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant tumor cells of different origin seem to have preferential sites for metastasis. Breast cancer, prostate cancer and certain melanomas have bone as one of their preferential targets for metastasis. Bone is continuously being remodelled, a process largely controlled by local growth factors. A possible explanation for malignant cell recruitment to bone is that osteoblast products, directly secreted or released from the matrix by osteoclast resorbing activity, are able to stimulate cancer cell migration. To test this hypothesis we have utilized an in vitro system of differentiating osteoblasts which in culture progress all the way to the formation of mineralized nodules. Conditioned media obtained from these osteoblast cultures at different stages were able to induce chemotactic migration and invasion of both melanoma and breast cancer cells. The migratory and invasive phenotype was accompanied by enhanced gelatinolytic activity of osteoblast stimulated cancer cells. Our data suggest that osteoblasts secrete potent factors able to direct tumor cell migration towards remodelling bone.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalCancer Letters
Volume97
Issue number1
DOIs
Publication statusPublished - Oct 20 1995

Keywords

  • Gelatinases
  • Invasion
  • Migration
  • Osteoblasts
  • Tumor cells

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

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