Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function

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Abstract

Paced breathing (PB) around 0.25 Hz has been advocated as a means to avoid confounding and to standardize measurements in short-term investigations of autonomic cardiovascular regulation. Controversy remains, however, as to whether it causes any alteration in autonomic control. We addressed this issue in 40 supine, middle-aged, healthy volunteers by assessing the changes induced by PB (0.25 Hz for 8 min) on 1) ventilatory parameters, 2) the indexes of autonomic control of cardiovascular function, and 3) the spectral indexes of cardiovascular variability. Subjects were grouped into group 1 (n = 31), if spontaneous breathing was regular and within the high-frequency (HF) band (0.15- 0.45 Hz), or group 2 (n = 9), if it was irregular or slow (2 decreased by [median (lower quartile, upper quartile)] -0.2 (-0.5, -0.1)% (group 1, P <0.0001) and -0.6 (-0.8, -0.5)% (group 2, P = 0.008). Mean R-R interval and systolic and diastolic pressure remained remarkably stable (all P ≥ 0.13, both groups). No significant changes were observed in spectral indexes of R-R and pressure variability (all P ≥ 0.12, measured only in group 1 to avoid confounding), except in the HF power of pressure signals, which significantly increased (all P <0.05) in association with increased tidal volume. In conclusion, PB at 0.25 Hz causes a slight hyperventilation and does not affect traditional indexes of autonomic control or, in subjects with spontaneous breathing in the HF band, most relevant spectral indexes of cardiovascular variability. These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume290
Issue number1
DOIs
Publication statusPublished - Jan 2006

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Respiration
Blood Pressure
Pressure
Hyperventilation
Tidal Volume
Healthy Volunteers

Keywords

  • Baroreflex sensitivity
  • Controlled breathing
  • Heart rate variability
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function",
abstract = "Paced breathing (PB) around 0.25 Hz has been advocated as a means to avoid confounding and to standardize measurements in short-term investigations of autonomic cardiovascular regulation. Controversy remains, however, as to whether it causes any alteration in autonomic control. We addressed this issue in 40 supine, middle-aged, healthy volunteers by assessing the changes induced by PB (0.25 Hz for 8 min) on 1) ventilatory parameters, 2) the indexes of autonomic control of cardiovascular function, and 3) the spectral indexes of cardiovascular variability. Subjects were grouped into group 1 (n = 31), if spontaneous breathing was regular and within the high-frequency (HF) band (0.15- 0.45 Hz), or group 2 (n = 9), if it was irregular or slow (2 decreased by [median (lower quartile, upper quartile)] -0.2 (-0.5, -0.1){\%} (group 1, P <0.0001) and -0.6 (-0.8, -0.5){\%} (group 2, P = 0.008). Mean R-R interval and systolic and diastolic pressure remained remarkably stable (all P ≥ 0.13, both groups). No significant changes were observed in spectral indexes of R-R and pressure variability (all P ≥ 0.12, measured only in group 1 to avoid confounding), except in the HF power of pressure signals, which significantly increased (all P <0.05) in association with increased tidal volume. In conclusion, PB at 0.25 Hz causes a slight hyperventilation and does not affect traditional indexes of autonomic control or, in subjects with spontaneous breathing in the HF band, most relevant spectral indexes of cardiovascular variability. These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing.",
keywords = "Baroreflex sensitivity, Controlled breathing, Heart rate variability, Spectral analysis",
author = "Pinna, {G. D.} and R. Maestri and {La Rovere}, {M. T.} and E. Gobbi and F. Fanfulla",
year = "2006",
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T1 - Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function

AU - Pinna, G. D.

AU - Maestri, R.

AU - La Rovere, M. T.

AU - Gobbi, E.

AU - Fanfulla, F.

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N2 - Paced breathing (PB) around 0.25 Hz has been advocated as a means to avoid confounding and to standardize measurements in short-term investigations of autonomic cardiovascular regulation. Controversy remains, however, as to whether it causes any alteration in autonomic control. We addressed this issue in 40 supine, middle-aged, healthy volunteers by assessing the changes induced by PB (0.25 Hz for 8 min) on 1) ventilatory parameters, 2) the indexes of autonomic control of cardiovascular function, and 3) the spectral indexes of cardiovascular variability. Subjects were grouped into group 1 (n = 31), if spontaneous breathing was regular and within the high-frequency (HF) band (0.15- 0.45 Hz), or group 2 (n = 9), if it was irregular or slow (2 decreased by [median (lower quartile, upper quartile)] -0.2 (-0.5, -0.1)% (group 1, P <0.0001) and -0.6 (-0.8, -0.5)% (group 2, P = 0.008). Mean R-R interval and systolic and diastolic pressure remained remarkably stable (all P ≥ 0.13, both groups). No significant changes were observed in spectral indexes of R-R and pressure variability (all P ≥ 0.12, measured only in group 1 to avoid confounding), except in the HF power of pressure signals, which significantly increased (all P <0.05) in association with increased tidal volume. In conclusion, PB at 0.25 Hz causes a slight hyperventilation and does not affect traditional indexes of autonomic control or, in subjects with spontaneous breathing in the HF band, most relevant spectral indexes of cardiovascular variability. These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing.

AB - Paced breathing (PB) around 0.25 Hz has been advocated as a means to avoid confounding and to standardize measurements in short-term investigations of autonomic cardiovascular regulation. Controversy remains, however, as to whether it causes any alteration in autonomic control. We addressed this issue in 40 supine, middle-aged, healthy volunteers by assessing the changes induced by PB (0.25 Hz for 8 min) on 1) ventilatory parameters, 2) the indexes of autonomic control of cardiovascular function, and 3) the spectral indexes of cardiovascular variability. Subjects were grouped into group 1 (n = 31), if spontaneous breathing was regular and within the high-frequency (HF) band (0.15- 0.45 Hz), or group 2 (n = 9), if it was irregular or slow (2 decreased by [median (lower quartile, upper quartile)] -0.2 (-0.5, -0.1)% (group 1, P <0.0001) and -0.6 (-0.8, -0.5)% (group 2, P = 0.008). Mean R-R interval and systolic and diastolic pressure remained remarkably stable (all P ≥ 0.13, both groups). No significant changes were observed in spectral indexes of R-R and pressure variability (all P ≥ 0.12, measured only in group 1 to avoid confounding), except in the HF power of pressure signals, which significantly increased (all P <0.05) in association with increased tidal volume. In conclusion, PB at 0.25 Hz causes a slight hyperventilation and does not affect traditional indexes of autonomic control or, in subjects with spontaneous breathing in the HF band, most relevant spectral indexes of cardiovascular variability. These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing.

KW - Baroreflex sensitivity

KW - Controlled breathing

KW - Heart rate variability

KW - Spectral analysis

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