Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic Type 1 (insulin-dependent) diabetic patients

A. Secchi, V. Di Carlo, S. Martinenghi, E. La Rocca, R. Caldara, D. Spotti, G. Slaviero, C. Staudacher, G. Ferrari, G. Pozza

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The aim of our study was to evaluate the effects of haemodialysis, kidney transplantation and simultaneous kidney and pancreas transplantation on survival of diabetic subjects and on kidney function. 40 Type 1 (insulin-dependent) diabetic patients received a kidney transplantation: in 31 cases the kidney was transplanted simultaneously to a pancreas graft from the same donor (KP group), while in 9 cases the pancreas was not available (K group). 44 uraemic Type 1(insulin-dependent) diabetic patients on dialysis and in waiting list for kidney transplantation, constituted the control group (HD group). Patient survival rate 1, 3 and 5 years following transplantation was better in KP group (93%, 89%, 89%, respectively) than in K group (88%, 88%, 73%, respectively) and in HD group (88%, 62%, 51%, respectively). Kidney graft survival at 1, 3 and 5 years post-transplant was better in KP group (93%, 72%, 72%, respectively) than in K group (76%, 61%, 31%, respectively). 1 year after transplantation, patients of the KP group who had lost the pancreas for technical reasons (thrombosis) were included in the K group so as to evaluate the effect of the transplanted pancreas on long-term patient and kidney survival. Patient survival rate in the KP group (17 patients) at 2 and 4 years was 100%, while at the same intervals it was 78% in the K group (13 patients). Kidney graft function rate at 2 and 4 years was 93% in the KP group (17 grafts) and 54% and 27% respectively in the K group (14 grafts). Evaluation of quality of life in patients receiving a kidney and pancreas transplantation showed an improvement in psychological well-being, when compared to patients receiving a kidney transplantation alone. Physical well-being was similar in patients transplanted with kidney and pancreas or with kidney alone.

Original languageEnglish
JournalDiabetologia
Volume34
Issue number1 Supplement
DOIs
Publication statusPublished - Aug 1991

Fingerprint

Pancreas Transplantation
Life Expectancy
Quality of Life
Insulin
Kidney
Kidney Transplantation
Pancreas
Transplants
Survival Rate
Transplantation
Waiting Lists
Graft Survival
Renal Dialysis
Dialysis
Thrombosis
Tissue Donors

Keywords

  • Kidney transplantation
  • Life expectancy
  • Pancreas transplantation
  • Quality of life

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic Type 1 (insulin-dependent) diabetic patients. / Secchi, A.; Di Carlo, V.; Martinenghi, S.; La Rocca, E.; Caldara, R.; Spotti, D.; Slaviero, G.; Staudacher, C.; Ferrari, G.; Pozza, G.

In: Diabetologia, Vol. 34, No. 1 Supplement, 08.1991.

Research output: Contribution to journalArticle

Secchi, A, Di Carlo, V, Martinenghi, S, La Rocca, E, Caldara, R, Spotti, D, Slaviero, G, Staudacher, C, Ferrari, G & Pozza, G 1991, 'Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic Type 1 (insulin-dependent) diabetic patients', Diabetologia, vol. 34, no. 1 Supplement. https://doi.org/10.1007/BF00587642
Secchi, A. ; Di Carlo, V. ; Martinenghi, S. ; La Rocca, E. ; Caldara, R. ; Spotti, D. ; Slaviero, G. ; Staudacher, C. ; Ferrari, G. ; Pozza, G. / Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic Type 1 (insulin-dependent) diabetic patients. In: Diabetologia. 1991 ; Vol. 34, No. 1 Supplement.
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abstract = "The aim of our study was to evaluate the effects of haemodialysis, kidney transplantation and simultaneous kidney and pancreas transplantation on survival of diabetic subjects and on kidney function. 40 Type 1 (insulin-dependent) diabetic patients received a kidney transplantation: in 31 cases the kidney was transplanted simultaneously to a pancreas graft from the same donor (KP group), while in 9 cases the pancreas was not available (K group). 44 uraemic Type 1(insulin-dependent) diabetic patients on dialysis and in waiting list for kidney transplantation, constituted the control group (HD group). Patient survival rate 1, 3 and 5 years following transplantation was better in KP group (93{\%}, 89{\%}, 89{\%}, respectively) than in K group (88{\%}, 88{\%}, 73{\%}, respectively) and in HD group (88{\%}, 62{\%}, 51{\%}, respectively). Kidney graft survival at 1, 3 and 5 years post-transplant was better in KP group (93{\%}, 72{\%}, 72{\%}, respectively) than in K group (76{\%}, 61{\%}, 31{\%}, respectively). 1 year after transplantation, patients of the KP group who had lost the pancreas for technical reasons (thrombosis) were included in the K group so as to evaluate the effect of the transplanted pancreas on long-term patient and kidney survival. Patient survival rate in the KP group (17 patients) at 2 and 4 years was 100{\%}, while at the same intervals it was 78{\%} in the K group (13 patients). Kidney graft function rate at 2 and 4 years was 93{\%} in the KP group (17 grafts) and 54{\%} and 27{\%} respectively in the K group (14 grafts). Evaluation of quality of life in patients receiving a kidney and pancreas transplantation showed an improvement in psychological well-being, when compared to patients receiving a kidney transplantation alone. Physical well-being was similar in patients transplanted with kidney and pancreas or with kidney alone.",
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AU - Caldara, R.

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