Effect of pH on in vitro biocompatibility of orthodontic miniscrew implants.

Angela Galeotti, Roberto Uomo, Gianrico Spagnuolo, Sergio Paduano, Roberta Cimino, Rosa Valletta, Vincenzo D'Antò

Research output: Contribution to journalArticlepeer-review


Although the clinical use of miniscrews has been investigated on a large scale, little is known about their biocompatibility. Since low pH can affect corrosion resistance, the aim of this study was to evaluate the cytotoxic effect of orthodontic miniscrews in different pH conditions. Four orthodontic miniscrews of stainless steel and grade IV and grade V titanium were immersed in a pH 7 and pH 4 saline solution for 1, 7, 14, 21, 28, and 84 days. Human osteogenic sarcoma cells (U2OS), permanent human keratinocytes (HaCat), and primary human gingival fibroblasts (HGF) were exposed to eluates, and the mitochondrial dehydrogenase activity was measured after 24 h to assess the cytoxicity. The results were analyzed using the Mann-Whitney U test (P

Original languageEnglish
Pages (from-to)15
Number of pages1
JournalProgress in Orthodontics
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Orthodontics


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