Effect of pharmacological wash-out in patients undergoing exercise testing after acute myocardial infarction

Riccardo Bigi, Alessandro Verzoni, Lauro Cortigiani, Benedetta De Chiara, Alessandro Desideri, Cesare Fiorentini

Research output: Contribution to journalArticle


Study objectives: Pharmacological therapy can reduce diagnostic and prognostic accuracy of exercise stress testing. However, the risk of withdrawing drugs early after myocardial infarction (MI) has not been established. We assessed safety and clinical implications of drug withdrawal in patients undergoing stress testing after uncomplicated MI. Methods: A total of 362 MI patients underwent ECG Holter recording before and after withdrawing beta-blockers, calcium-antagonists and nitrates. QRS (QRS/h) and ventricular premature beats (VPB/h) count per hour, repetitive ventricular arrhythmias, ST segment changes and patient complaints were evaluated for reproducibility using kappa statistics and Bland-Altman method. Results: No major complications occurred. Forty-three patients complained of >1 symptom on and 37 off therapy. QRS/h and VPB/h count were significantly (p

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - Nov 2004



  • Acute myocardial infarction
  • ECG Holter monitoring
  • Exercise stress testing
  • Pharmacological therapy
  • Prognostic stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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