Effect of pharmacological wash-out in patients undergoing exercise testing after acute myocardial infarction

Riccardo Bigi, Alessandro Verzoni, Lauro Cortigiani, Benedetta De Chiara, Alessandro Desideri, Cesare Fiorentini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Study objectives: Pharmacological therapy can reduce diagnostic and prognostic accuracy of exercise stress testing. However, the risk of withdrawing drugs early after myocardial infarction (MI) has not been established. We assessed safety and clinical implications of drug withdrawal in patients undergoing stress testing after uncomplicated MI. Methods: A total of 362 MI patients underwent ECG Holter recording before and after withdrawing beta-blockers, calcium-antagonists and nitrates. QRS (QRS/h) and ventricular premature beats (VPB/h) count per hour, repetitive ventricular arrhythmias, ST segment changes and patient complaints were evaluated for reproducibility using kappa statistics and Bland-Altman method. Results: No major complications occurred. Forty-three patients complained of >1 symptom on and 37 off therapy. QRS/h and VPB/h count were significantly (p

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalInternational Journal of Cardiology
Volume97
Issue number2
DOIs
Publication statusPublished - Nov 2004

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Myocardial Infarction
Pharmacology
Exercise
Ventricular Premature Complexes
Pharmaceutical Preparations
Cardiac Arrhythmias
Electrocardiography
Safety
Therapeutics

Keywords

  • Acute myocardial infarction
  • ECG Holter monitoring
  • Exercise stress testing
  • Pharmacological therapy
  • Prognostic stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of pharmacological wash-out in patients undergoing exercise testing after acute myocardial infarction. / Bigi, Riccardo; Verzoni, Alessandro; Cortigiani, Lauro; De Chiara, Benedetta; Desideri, Alessandro; Fiorentini, Cesare.

In: International Journal of Cardiology, Vol. 97, No. 2, 11.2004, p. 277-281.

Research output: Contribution to journalArticle

Bigi, Riccardo ; Verzoni, Alessandro ; Cortigiani, Lauro ; De Chiara, Benedetta ; Desideri, Alessandro ; Fiorentini, Cesare. / Effect of pharmacological wash-out in patients undergoing exercise testing after acute myocardial infarction. In: International Journal of Cardiology. 2004 ; Vol. 97, No. 2. pp. 277-281.
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