Effect of phototherapy on the physiologic cholestasis of the neonate

Nathan Levi, Marina Trevisan, Roberto Perini, Giorgio Tamaro, Giuliano Torre, Claudio Tiribelli

Research output: Contribution to journalArticle

Abstract

Phototherapy (PT) has been reported to increase bile acid excretion in the bile of adults with liver cirrhosis. We investigated the effect of PT on the levels of serum total bile acids (STBA), conjugated cholic acid (CCA), conjugated chenodeoxycholic acid (CCDCA), conjugated lithocholic acid (CLCA), and sulfolithocho-lylglycine (SLCG) in 13 neonates with unconjugated nonhemolytic hyperbilirubinemia before and after 12 h of PT. The treatment produced a statistically significant (p <0. 02) reduction in both STB A and CCA levels, whereas no effect on the other fractions was observed. The percentage of reduction was the same for STBA and CCA concentrations, indicating that the effect is related to a specific reduction in CCA levels. The magnitude of the expected decrease in the level of serum bilirubin is not correlated with that in bile acids in individual cases. The data are interpreted as suggesting that PT can affect the metabolism of bile acids by decreasing STBA and CCA levels in neonates through an increase in their biliary excretion associated with the reduced intestinal absorption of CCA occurring in newborns.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume3
Issue number2
Publication statusPublished - 1984

Fingerprint

cholic acid
Cholic Acid
cholestasis
Phototherapy
Cholestasis
bile acids
Bile Acids and Salts
neonates
Serum
excretion
lithocholic acid
chenodeoxycholic acid
Lithocholic Acid
hyperbilirubinemia
Chenodeoxycholic Acid
liver cirrhosis
Hyperbilirubinemia
intestinal absorption
Intestinal Absorption
bilirubin

Keywords

  • Bile acids
  • Bilirubin
  • Cholic acid
  • Intestinal absorption
  • Phototherapy

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Histology
  • Medicine (miscellaneous)
  • Food Science

Cite this

Levi, N., Trevisan, M., Perini, R., Tamaro, G., Torre, G., & Tiribelli, C. (1984). Effect of phototherapy on the physiologic cholestasis of the neonate. Journal of Pediatric Gastroenterology and Nutrition, 3(2), 230-233.

Effect of phototherapy on the physiologic cholestasis of the neonate. / Levi, Nathan; Trevisan, Marina; Perini, Roberto; Tamaro, Giorgio; Torre, Giuliano; Tiribelli, Claudio.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 3, No. 2, 1984, p. 230-233.

Research output: Contribution to journalArticle

Levi, N, Trevisan, M, Perini, R, Tamaro, G, Torre, G & Tiribelli, C 1984, 'Effect of phototherapy on the physiologic cholestasis of the neonate', Journal of Pediatric Gastroenterology and Nutrition, vol. 3, no. 2, pp. 230-233.
Levi, Nathan ; Trevisan, Marina ; Perini, Roberto ; Tamaro, Giorgio ; Torre, Giuliano ; Tiribelli, Claudio. / Effect of phototherapy on the physiologic cholestasis of the neonate. In: Journal of Pediatric Gastroenterology and Nutrition. 1984 ; Vol. 3, No. 2. pp. 230-233.
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