TY - JOUR
T1 - Effect of piribedil and one of its metabolites on the concentration of homovanillic acid in the rat brain
AU - Jori, Armanda
AU - Cecchetti, Giancarlo
AU - Dolfini, Enzo
AU - Monti, Elena
AU - Garattini, Silvio
PY - 1974
Y1 - 1974
N2 - Piribedil and its metabolite (pyrimidyl-2′)-1-(dihydroxy-3′,4′-benzyl)-4-piperazine dichlorhydrate (PdHBP), like apomorphine, decrease the level of HVa in the rat striatum. The effect appears rapidly and it lasts for about 2 hr. Piribedil antagonizes the rise of striatal HVA elicited by chlorpromazine, haloperidol and fenfluramine. Piribedil, PdHBP and apomorphine did not counteract the increase of striatal HVA induced by d-amphetamine.
AB - Piribedil and its metabolite (pyrimidyl-2′)-1-(dihydroxy-3′,4′-benzyl)-4-piperazine dichlorhydrate (PdHBP), like apomorphine, decrease the level of HVa in the rat striatum. The effect appears rapidly and it lasts for about 2 hr. Piribedil antagonizes the rise of striatal HVA elicited by chlorpromazine, haloperidol and fenfluramine. Piribedil, PdHBP and apomorphine did not counteract the increase of striatal HVA induced by d-amphetamine.
KW - Amphetamine
KW - Dopamine metabolism
KW - Fenfluramine
KW - Homovanillic acid (HVA)
KW - Neuroleptic drugs
KW - Piribedil
KW - Trivastal
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U2 - 10.1016/0014-2999(74)90152-6
DO - 10.1016/0014-2999(74)90152-6
M3 - Article
C2 - 4851685
AN - SCOPUS:0016138657
VL - 27
SP - 245
EP - 248
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -