Effect of piribedil and one of its metabolites on the concentration of homovanillic acid in the rat brain

Armanda Jori, Giancarlo Cecchetti, Enzo Dolfini, Elena Monti, Silvio Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Piribedil and its metabolite (pyrimidyl-2′)-1-(dihydroxy-3′,4′-benzyl)-4-piperazine dichlorhydrate (PdHBP), like apomorphine, decrease the level of HVa in the rat striatum. The effect appears rapidly and it lasts for about 2 hr. Piribedil antagonizes the rise of striatal HVA elicited by chlorpromazine, haloperidol and fenfluramine. Piribedil, PdHBP and apomorphine did not counteract the increase of striatal HVA induced by d-amphetamine.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalEuropean Journal of Pharmacology
Volume27
Issue number2
DOIs
Publication statusPublished - 1974

Keywords

  • Amphetamine
  • Dopamine metabolism
  • Fenfluramine
  • Homovanillic acid (HVA)
  • Neuroleptic drugs
  • Piribedil
  • Trivastal

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Fingerprint

Dive into the research topics of 'Effect of piribedil and one of its metabolites on the concentration of homovanillic acid in the rat brain'. Together they form a unique fingerprint.

Cite this