TY - JOUR
T1 - Effect of pistachio on brachial artery diameter and flow-mediated dilatation
T2 - A systematic review and meta-analysis of randomized, controlled-feeding clinical studies
AU - Fogacci, Federica
AU - Cicero, Arrigo F.G.
AU - Derosa, Giuseppe
AU - Rizzo, Manfredi
AU - Veronesi, Maddalena
AU - Borghi, Claudio
PY - 2019/1/19
Y1 - 2019/1/19
N2 - Background: Results of previous clinical trials evaluating the effect of pistachio supplementation on endothelial reactivity (ER) are controversial. Aims: We aimed to assess the impact of pistachio on ER through systematic review of literature and meta-analysis of available randomized, controlled-feeding clinical studies (RCTs). Methods: The literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 1st August 2017 to identify RCTs investigating the impact of pistachio on ER. Two independent reviewers extracted data on study characteristics, methods and outcomes. Overall, the impact of pistachio on ER was reported in 4 trials. Results: The meta-analysis did not suggest a significant change in brachial artery flow-mediated dilatation (FMD) (WMD: +0.28%; 95%CI: −0.58, 1.13; p = 0.525) while brachial artery diameter (BAD) improved (WMD: +0.04%; 95%CI: 0.03, 0.06; p<0.001) following pistachios consumption. Conclusion: The present meta-analysis suggests a significant effect of pistachios on ER, affecting BAD but not FMD.
AB - Background: Results of previous clinical trials evaluating the effect of pistachio supplementation on endothelial reactivity (ER) are controversial. Aims: We aimed to assess the impact of pistachio on ER through systematic review of literature and meta-analysis of available randomized, controlled-feeding clinical studies (RCTs). Methods: The literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 1st August 2017 to identify RCTs investigating the impact of pistachio on ER. Two independent reviewers extracted data on study characteristics, methods and outcomes. Overall, the impact of pistachio on ER was reported in 4 trials. Results: The meta-analysis did not suggest a significant change in brachial artery flow-mediated dilatation (FMD) (WMD: +0.28%; 95%CI: −0.58, 1.13; p = 0.525) while brachial artery diameter (BAD) improved (WMD: +0.04%; 95%CI: 0.03, 0.06; p<0.001) following pistachios consumption. Conclusion: The present meta-analysis suggests a significant effect of pistachios on ER, affecting BAD but not FMD.
KW - brachial artery diameter
KW - endothelial reactivity
KW - flow mediated dilatation
KW - meta-analysis
KW - Pistachio
UR - http://www.scopus.com/inward/record.url?scp=85063628018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063628018&partnerID=8YFLogxK
U2 - 10.1080/10408398.2017.1368007
DO - 10.1080/10408398.2017.1368007
M3 - Review article
AN - SCOPUS:85063628018
VL - 59
SP - 328
EP - 335
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
SN - 1040-8398
IS - 2
ER -