Effect of pistachio on brachial artery diameter and flow-mediated dilatation: A systematic review and meta-analysis of randomized, controlled-feeding clinical studies

Federica Fogacci, Arrigo F.G. Cicero, Giuseppe Derosa, Manfredi Rizzo, Maddalena Veronesi, Claudio Borghi

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Results of previous clinical trials evaluating the effect of pistachio supplementation on endothelial reactivity (ER) are controversial. Aims: We aimed to assess the impact of pistachio on ER through systematic review of literature and meta-analysis of available randomized, controlled-feeding clinical studies (RCTs). Methods: The literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 1st August 2017 to identify RCTs investigating the impact of pistachio on ER. Two independent reviewers extracted data on study characteristics, methods and outcomes. Overall, the impact of pistachio on ER was reported in 4 trials. Results: The meta-analysis did not suggest a significant change in brachial artery flow-mediated dilatation (FMD) (WMD: +0.28%; 95%CI: −0.58, 1.13; p = 0.525) while brachial artery diameter (BAD) improved (WMD: +0.04%; 95%CI: 0.03, 0.06; p<0.001) following pistachios consumption. Conclusion: The present meta-analysis suggests a significant effect of pistachios on ER, affecting BAD but not FMD.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalCritical Reviews in Food Science and Nutrition
Volume59
Issue number2
DOIs
Publication statusPublished - Jan 19 2019

Keywords

  • brachial artery diameter
  • endothelial reactivity
  • flow mediated dilatation
  • meta-analysis
  • Pistachio

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

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