Effect of platelet concentrate on quality of life after periradicular surgery: A randomized clinical study

Massimo Del Fabbro, Valentina Ceresoli, Alessandra Lolato, Silvio Taschieri

Research output: Contribution to journalArticle


Introduction: Control of postoperative discomfort might enhance the patient's quality of life and treatment acceptance. The aim of the present randomized single-blind study was to evaluate whether the use of platelet concentrate during endodontic surgery might have a favorable impact on pain and other factors related to patient's quality of life during the first week after surgery. Methods: Eighteen patients with periapical lesion were treated with modern endodontic surgical procedure (control group). In another 18 patients, in adjunct to surgical procedure, platelet concentrate was applied on the root end in liquid form, within the bone defect in clot form, and over the suture in liquid form (test group). All patients completed a questionnaire for evaluation of main symptoms and daily activities during the first week after surgery. The outcomes of the questionnaires of the 2 groups were statistically compared. Results: The test group showed significantly less pain and swelling, fewer analgesics taken, and improved functional activities as compared with the control group. Conclusions: The adjunct of platelet concentrate to the endodontic surgical procedure produced significant beneficial effect to patients' quality of life during the early postoperative stage.

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalJournal of Endodontics
Issue number6
Publication statusPublished - Jun 2012



  • Endodontic surgery
  • growth factors
  • periapical lesion
  • platelet concentrate
  • quality of life

ASJC Scopus subject areas

  • Dentistry(all)

Cite this