Effect of pre-infarction angina on platelet reactivity in acute myocardial infarction

Giancarla Scalone, Cristina Aurigemma, Fabrizio Tomai, Pierfrancesco Corvo, Irma Battipaglia, Gaetano A. Lanza, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background: Previous studies demonstrated that patients with PIA have a smaller infarct and better in-hospital outcome after acute myocardial infarction, than those without angina. This protective effects has been attributed to ischemic preconditioning (PC), to earlier reperfusion after fibrinolysis or its better collateral circulation development. In this study we aimed at assessing platelet reactivity in patients with history of pre-infarction angina (PIA) in the acute phase of ST segment elevation myocardial infarction (STEMI) and 1 month later. Methods: 85 consecutive patients (63 ± 10.5 years, 60 male) with a first STEMI treated by primary percutaneous coronary intervention (PCI) were studied at admission and 1 month later. Platelet reactivity was evaluated by flow cyometry with and without adenosine diphosphate (ADP) stimulation, by measuring monocyte-platelet aggregates (MPAs) and glycoprotein IIb/IIIa (CD41) expression in the MPA gate, and CD41 and fibrinogen receptor (PAC-1) expression in the platelet gate. Results: MPAs and expression of platelet receptors CD41 and PAC-1 were significantly lower in patients with than patients without PIA, both with and without ADP stimulation. After 1 month, all cytometry variables both with and without ADP stimulation were similar in the two groups. Conclusions: This study shows, for the first time, that patients with a first STEMI who experience PIA show a lower platelet reactivity as compared with those without history of PIA.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalInternational Journal of Cardiology
Volume167
Issue number1
DOIs
Publication statusPublished - Jul 15 2013

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Keywords

  • Platelet reactivity
  • Pre-infarction angina
  • Primary percutaneous intervention
  • ST segment elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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