Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Stefano Palomba, Angela Falbo, Francesco Orio, Fulvio Zullo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the effect of pregestational metformin administration on abortion risk in polycystic ovary syndrome (PCOS) patients. Design: Systematic review and meta-analysis. Setting: Academic Department of Obstetrics and Gynecology in Italy. Patient(s): Women affected by PCOS receiving pregestational metformin. Intervention(s): Systematic review of randomized controlled trials (RCTs) published up to June 2008 and subsequent meta-analysis. Main Outcome Measure(s): Abortion rate. Result(s): Seventeen RCTs were included in the final analysis. Overall, no effect of the metformin administration was detected on the abortion risk. No statistically significant effect of metformin on the abortion risk was observed in any comparison when subgrouping the RCTs according to received treatment. Conclusion(s): Metformin has no effect on the abortion risk in PCOS patients when administered before pregnancy.

Original languageEnglish
Pages (from-to)1646-1658
Number of pages13
JournalFertility and Sterility
Volume92
Issue number5
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Abortion
  • metformin
  • miscarriage
  • polycystic ovary syndrome
  • treatment

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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