Efecto de metformina preconcepcional sobre el riesgo de aborto en síndrome de ovario poliquístico: Una revisión sistemática y meta-análisis de ensayos controlados randomizados

Translated title of the contribution: Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials

Stefano Palomba, Angela Falbo, Francesco Orio, Fulvio Zullo

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of pregestational metformin administration on abortion risk in polycystic ovary syndrome (PCOS) patients. Design: Systematic review and meta-analysis. Setting: Academic Department of Obstetrics and Gynecology in Italy. Patient(s): Women affected by PCOS receiving pregestational metformin. Intervention(s): Systematic review of randomized controlled trials (RCTs) published up to June 2008 and subsequent meta-analysis. Main Outcome Measure(s): Abortion rate. Result(s): Seventeen RCTs were included in the final analysis. Overall, no effect of the metformin administration was detected on the abortion risk. No statistically significant effect of metformin on the abortion risk was observed in any comparison when subgrouping the RCTs according to received treatment. Conclusion(s): Metformin has no effect on the abortion risk in PCOS patients when administered before pregnancy.

Translated title of the contributionEffect of preconceptional metformin on abortion risk in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
Original languageSpanish
Pages (from-to)533-549
Number of pages17
JournalRevista Iberoamericana de Fertilidad y Reproduccion Humana
Volume26
Issue number6
Publication statusPublished - Nov 2009

Keywords

  • Abortion
  • Metformin
  • Miscarriage
  • Polycystic ovary syndrome
  • Treatment

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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