TY - JOUR
T1 - Effect of preservative-free tafluprost on keratocytes, sub-basal nerves, and endothelium
T2 - A single-blind one-year confocal study on naïve or treated glaucoma and hypertensive patients versus a control group
AU - Rossi, Gemma Caterina Maria
AU - Blini, Mirella
AU - Scudeller, Luigia
AU - Ricciardelli, Gabriella
AU - Depolo, Laura
AU - Amisano, Alberto
AU - Bossolesi, Laura
AU - Pasinetti, Gian Maria
AU - Bianchi, Paolo Emilio
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Purpose: To record the impact of preservative-free Tafluprost on corneal status examined by in vivo confocal microscopy. Methods: A prospective cohort study on consecutive naïve or previously treated patients with a new prescription of preservative-free Tafluprost. All subjects underwent a complete ophthalmic examination [comprehensive of intraocular pressure (IOP) and central corneal thickness (CCT) measurements], and an in vivo corneal confocal microscopy evaluation, at baseline and 12 months later. A healthy control group was selected and examined at the same time. Results: Seventy-five subjects (16 controls, 20 naïve, and 39 treated) were enrolled. At baseline, IOP was 16 (13.8-18.6), 21.5 (18-23.7), and 18 (16-22) mmHg, (P=0.01); and CCT did not differ among the groups (P=0.25). Epithelial cells, keratocyte activation, a number of sub-basal nerves, and the grade of nerve tortuosity were similar (P=0.233, 0.11, 0.417, and 0.05, respectively), in naïve and controls, while previously treated patients had significantly less epithelial cells and sub-basal corneal nerves (P
AB - Purpose: To record the impact of preservative-free Tafluprost on corneal status examined by in vivo confocal microscopy. Methods: A prospective cohort study on consecutive naïve or previously treated patients with a new prescription of preservative-free Tafluprost. All subjects underwent a complete ophthalmic examination [comprehensive of intraocular pressure (IOP) and central corneal thickness (CCT) measurements], and an in vivo corneal confocal microscopy evaluation, at baseline and 12 months later. A healthy control group was selected and examined at the same time. Results: Seventy-five subjects (16 controls, 20 naïve, and 39 treated) were enrolled. At baseline, IOP was 16 (13.8-18.6), 21.5 (18-23.7), and 18 (16-22) mmHg, (P=0.01); and CCT did not differ among the groups (P=0.25). Epithelial cells, keratocyte activation, a number of sub-basal nerves, and the grade of nerve tortuosity were similar (P=0.233, 0.11, 0.417, and 0.05, respectively), in naïve and controls, while previously treated patients had significantly less epithelial cells and sub-basal corneal nerves (P
UR - http://www.scopus.com/inward/record.url?scp=84887033433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887033433&partnerID=8YFLogxK
U2 - 10.1089/jop.2013.0069
DO - 10.1089/jop.2013.0069
M3 - Article
C2 - 23944905
AN - SCOPUS:84887033433
VL - 29
SP - 821
EP - 825
JO - Journal of Ocular Pharmacology and Therapeutics
JF - Journal of Ocular Pharmacology and Therapeutics
SN - 1080-7683
IS - 9
ER -