Effect of preservative-free tafluprost on keratocytes, sub-basal nerves, and endothelium: A single-blind one-year confocal study on naïve or treated glaucoma and hypertensive patients versus a control group

Gemma Caterina Maria Rossi, Mirella Blini, Luigia Scudeller, Gabriella Ricciardelli, Laura Depolo, Alberto Amisano, Laura Bossolesi, Gian Maria Pasinetti, Paolo Emilio Bianchi

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Purpose: To record the impact of preservative-free Tafluprost on corneal status examined by in vivo confocal microscopy. Methods: A prospective cohort study on consecutive naïve or previously treated patients with a new prescription of preservative-free Tafluprost. All subjects underwent a complete ophthalmic examination [comprehensive of intraocular pressure (IOP) and central corneal thickness (CCT) measurements], and an in vivo corneal confocal microscopy evaluation, at baseline and 12 months later. A healthy control group was selected and examined at the same time. Results: Seventy-five subjects (16 controls, 20 naïve, and 39 treated) were enrolled. At baseline, IOP was 16 (13.8-18.6), 21.5 (18-23.7), and 18 (16-22) mmHg, (P=0.01); and CCT did not differ among the groups (P=0.25). Epithelial cells, keratocyte activation, a number of sub-basal nerves, and the grade of nerve tortuosity were similar (P=0.233, 0.11, 0.417, and 0.05, respectively), in naïve and controls, while previously treated patients had significantly less epithelial cells and sub-basal corneal nerves (P

Original languageEnglish
Pages (from-to)821-825
Number of pages5
JournalJournal of Ocular Pharmacology and Therapeutics
Issue number9
Publication statusPublished - Nov 1 2013


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Ophthalmology
  • Pharmacology

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