Effect of primary coronary intervention on heart rate variability and left ventricular function in patients with acute myocardial infarction

P. Santangeli, P. Lamendola, C. Larosa, A. Lombardo, A. Sestito, F. Infusino, G. A. Sgueglia, L. Mariani, L. Marinaccio, G. A. Lanza, F. Crea

Research output: Contribution to journalArticle

Abstract

Aim. Several studies showed that primary percutaneous coronary interventions (PCI) have a favourable impact on left ventricular remodeling and heart rate variability (HRV) both at short- and long-term follow-up in patients suffering an acute myocardial infarction (AMI). However, no previous study investigated the relationship between left ventricular remodeling and changes in HRV during follow-up in AMI patients treated by primary PCI. Methods. We studied 28 patients with AMI (57±8 years, 27 men), treated by PCI within 12 hours of symptom onset. Patients underwent a 24-hour ECG Holter recording and left ventricular ejection fraction (LVEF) echocardiographic assessment before discharge, and at 1-month and 6-month follow-up. HRV was measured in the time- and frequency-domain. Results. A significant improvement of both time- and frequency-domain HRV variables was observed at 1-month and at 6-month follow-up with the most significant changes being found for standard deviation of normal-normal beat intervals (SDNN) in the time-domain (95.5±26.1 ms vs 125.5±29.8 ms vs 142.8±28.8 ms, respectively; P

Original languageEnglish
Pages (from-to)703-710
Number of pages8
JournalMinerva Cardioangiologica
Volume55
Issue number6
Publication statusPublished - Dec 2007

Keywords

  • Angioplasty, transluminal, percutaneous coronary
  • Heart rate
  • Myocardial infarction
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Santangeli, P., Lamendola, P., Larosa, C., Lombardo, A., Sestito, A., Infusino, F., Sgueglia, G. A., Mariani, L., Marinaccio, L., Lanza, G. A., & Crea, F. (2007). Effect of primary coronary intervention on heart rate variability and left ventricular function in patients with acute myocardial infarction. Minerva Cardioangiologica, 55(6), 703-710.