TY - JOUR
T1 - Effect of prolonged treatment with propionyl-L-carnitine on erucic acid-induced myocardial dysfunction in rats
AU - Pasini, E.
AU - Cargnoni, A.
AU - Condorelli, E.
AU - Marzo, A.
AU - Lisciani, R.
AU - Ferrari, R.
PY - 1992/6
Y1 - 1992/6
N2 - The aim of this study was to evaluate the ability of propionyl-L-carnitine to prevent cardiac damage induced by erucic acid. Rats were fed for 10 days with normal or 10% erucic acid-enriched diets with or without propionyl-L-carnitine intraperitoneally injected, (1 mM/kg daily, for 10 days). The erucic acid diet produced increases in triglycerides (from 5.6 to 12.4 mg/gww, P <0.01), and free fatty acids (from 2.0 to 5.1 mg/gww, P <0.01), but no changes in phospholipids. When the hearts were perfused aerobically with an isovolumic preparation there was no difference in mechanical activity. On the contrary, when pressure-volume curves were determined, the pressure developed by hearts from the erucic acid-treated rats were reduced. Independent of diet, propionyl-L-carnitine treatment always produced positive inotropy. This was concomitant with improved mitochondrial respiration (RCI 5.1 vs 9.3, P <0.01), higher tissue ATP content (10.3 vs 18.4 μmol/gdw P <0.01) and reduction of triglycerides (12.4 vs 8.0 mg/gww, P <0.01). These data suggest that propionyl-L-carnitine, when given chronically, is able to prevent erucic acid-induced cardiotoxicity, probably by reducing triglyceride accumulation and improving energy metabolism.
AB - The aim of this study was to evaluate the ability of propionyl-L-carnitine to prevent cardiac damage induced by erucic acid. Rats were fed for 10 days with normal or 10% erucic acid-enriched diets with or without propionyl-L-carnitine intraperitoneally injected, (1 mM/kg daily, for 10 days). The erucic acid diet produced increases in triglycerides (from 5.6 to 12.4 mg/gww, P <0.01), and free fatty acids (from 2.0 to 5.1 mg/gww, P <0.01), but no changes in phospholipids. When the hearts were perfused aerobically with an isovolumic preparation there was no difference in mechanical activity. On the contrary, when pressure-volume curves were determined, the pressure developed by hearts from the erucic acid-treated rats were reduced. Independent of diet, propionyl-L-carnitine treatment always produced positive inotropy. This was concomitant with improved mitochondrial respiration (RCI 5.1 vs 9.3, P <0.01), higher tissue ATP content (10.3 vs 18.4 μmol/gdw P <0.01) and reduction of triglycerides (12.4 vs 8.0 mg/gww, P <0.01). These data suggest that propionyl-L-carnitine, when given chronically, is able to prevent erucic acid-induced cardiotoxicity, probably by reducing triglyceride accumulation and improving energy metabolism.
KW - cardiomyopathy
KW - erucic acid
KW - heart failure
KW - propionyl-L-carnitine
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U2 - 10.1007/BF00227568
DO - 10.1007/BF00227568
M3 - Article
C2 - 1640928
AN - SCOPUS:0026719793
VL - 112
SP - 117
EP - 123
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 2
ER -