Effect of prolonged treatment with propionyl-L-carnitine on erucic acid-induced myocardial dysfunction in rats

E. Pasini, A. Cargnoni, E. Condorelli, A. Marzo, R. Lisciani, R. Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the ability of propionyl-L-carnitine to prevent cardiac damage induced by erucic acid. Rats were fed for 10 days with normal or 10% erucic acid-enriched diets with or without propionyl-L-carnitine intraperitoneally injected, (1 mM/kg daily, for 10 days). The erucic acid diet produced increases in triglycerides (from 5.6 to 12.4 mg/gww, P <0.01), and free fatty acids (from 2.0 to 5.1 mg/gww, P <0.01), but no changes in phospholipids. When the hearts were perfused aerobically with an isovolumic preparation there was no difference in mechanical activity. On the contrary, when pressure-volume curves were determined, the pressure developed by hearts from the erucic acid-treated rats were reduced. Independent of diet, propionyl-L-carnitine treatment always produced positive inotropy. This was concomitant with improved mitochondrial respiration (RCI 5.1 vs 9.3, P <0.01), higher tissue ATP content (10.3 vs 18.4 μmol/gdw P <0.01) and reduction of triglycerides (12.4 vs 8.0 mg/gww, P <0.01). These data suggest that propionyl-L-carnitine, when given chronically, is able to prevent erucic acid-induced cardiotoxicity, probably by reducing triglyceride accumulation and improving energy metabolism.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume112
Issue number2
DOIs
Publication statusPublished - Jun 1992

Keywords

  • cardiomyopathy
  • erucic acid
  • heart failure
  • propionyl-L-carnitine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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