Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart

R. Ferrari, E. Pasini, E. Condorelli, A. Boraso, R. Lisciani, A. Marzo, O. Visiou

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10-9 to 10-3 M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalCardiovascular Drugs and Therapy
Volume5
Issue number1 Supplement
DOIs
Publication statusPublished - Feb 1991

Keywords

  • myocardial contractility
  • pharmacokinetic
  • propionyl-L-carnitine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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