Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis

I. Martinelli, P. Bucciarelli, V. De Stefano, S. M. Passamonti, M. Menegatti, D. Tormene, A. Tosetto, P. M. Mannucci

Research output: Contribution to journalArticle

Abstract

Background and Purpose: The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not known.Methods: The presence of prothrombin 19911 A>G was investigated in a case-control study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25), prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842 healthy individuals with the corresponding coagulation profile.Results: Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6-4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6-2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5-3.1).Conclusions: Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA.

Original languageEnglish
Pages (from-to)1482-1485
Number of pages4
JournalEuropean Journal of Neurology
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Cerebral vein thrombosis
  • Factor V Leiden
  • Prothrombin mutation
  • Risk factors
  • Thrombophilia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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