Effect of pulmonary rehabilitation on exhaled nitric oxide in patients with chronic obstructive pulmonary disease

E. Clini, L. Bianchi, K. Foglio, R. Porta, M. Vitacca, N. Ambrosino

Research output: Contribution to journalArticle

Abstract

Background - In patients with mild to moderate chronic obstructive pulmonary disease (COPD) the exercise induced increase in exhaled nitric oxide (eNO) parallels that observed in normal untrained subjects. There is no information on the effects of the level of exercise tolerance on eNO in these patients. The aim of this study was to evaluate the effect of a pulmonary rehabilitation programme including exercise training on eNO in patients with COPD. Methods - In 14 consecutive male patients with stable COPD of mean (SD) age 64 (9) years and forced expiratory volume in one second (FEV1) 55 (14)% predicted, fractional eNO concentration (FeNO), peak work rate (Wpeak) and oxygen uptake (Vo2peak) were assessed at baseline (T-1), at the end of a 1 month run in period (T0), and after an 8 week outpatient multidisciplinary pulmonary rehabilitation programme (T1) including cycloergometer training. Results - FeNO did not significantly differ at T-1 and T0 (mean (SE) 4.3 (0.6) and 4.4 (0.6) ppb, respectively), whereas it rose significantly at T1 to 6.4 (0.7) ppb (p2 were significantly (p2peak from 1.27 (0.1) 1/min to 1.48 (0.1) 1/min). A significant correlation was found between baseline FEV1 and the change in FeNO following the rehabilitation programme (r=-0.71; p

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalThorax
Volume56
Issue number7
DOIs
Publication statusPublished - 2001

Keywords

  • Chronic obstructive pulmonary disease
  • Exercise training
  • Exhaled nitric oxide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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