Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs

Milena Fini, Paola Torricelli, Gianluca Giavaresi, Nicolò Nicoli Aldini, Francesco Cavani, Stefania Setti, Andrea Nicolini, Angelo Carpi, Roberto Giardino

Research output: Contribution to journalArticlepeer-review

Abstract

It has been demonstrated that pulsed electromagnetic field (PEMF) stimulation has a chondroprotective effect on osteoarthritis (OA) progression in the knee joints of the 12-month-old guinea pigs. The aim of the present study was to discover whether the therapeutic efficacy of PEMFs was maintained in older animals also in more severe OA lesions. PEMFs were administered daily (6 h/day for 6 months) to 15-month-old guinea pigs. The knee joints (medial and lateral tibial plateaus, medial and lateral femoral condyles) were evaluated by means of a histological/histochemical Mankin modified by Carlsson grading score and histomorphometric measurements of cartilage thickness (CT), fibrillation index (FI), subchondral bone thickness (SBT) and epiphyseal bone microarchitecture (bone volume: BV/TV; trabecular thickness: Tb.Th; trabecular number: Tb.N; trabecular separation: Tb.SP). Periarticular knee bone was also evaluated with dual X-ray absorptiometry (DXA). PEMF stimulation significantly changed the progression of OA lesions in all examined knee areas. In the most affected area of the knee joint (medial tibial plateau), significant lower histochemical score (p <0.0005), FI (p <0.005), SBT (p <0.05), BV/TV (p <0.0005), Tb.Th (p <0.05) and Tb.N (p <0.05) were observed while CT (p <0.05) and Tb.Sp (p <0.0005) were significantly higher than in SHAM-treated animals. DXA confirmed the significantly higher bone density in SHAM-treated animals. Even in the presence of severe OA lesions PEMFs maintained a significant efficacy in reducing lesion progression.

Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalBiomedicine and Pharmacotherapy
Volume62
Issue number10
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Chondroprotection
  • Guinea pig
  • Osteoarthritis
  • Pulsed electromagnetic fields

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs'. Together they form a unique fingerprint.

Cite this