Effect of pulsed electromagnetic fields on ovariectomized rats

Gianluca Giavaresi, Milena Fini, Saverio Gnudi, Lucia Martini, Romano Mongiorgi, Nicolò Nicoli Aldini, Allesandro Zati, Roberto Giardino

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Sixty Sprague-Dawley rats (10 months old, body weight 400 ± 25 g) were randomized into six groups of 10 animals each, to study the effect of pulsed electromagnetic fields (PEMFs) on the treatment of ovariectomized osteopenic rats. One group was used as baseline (Baseline). Four groups were ovariectomized, and another was sham-operated (Sham). Three ovariectomized groups were given three different PEMFs of the same intensity (7 mT) for 1 h a day for 16 weeks. Groups OVX-50 and OVX-100 were subjected to monodirectional sine-wave PEMFs with different frequencies (50 and 100 Hz), while Group OVX-72 was subjected to 72-Hz bidirectional square-wave PEMFs. Group Sham and an unexposed ovariectomized group (OVX) were used as therapy controls. Differences were observed for densitometric, biomechanical, and histomorphometric data (p <0.005), particularly between the ovariectomized groups and the non-ovariectomized groups. Monthly food consumption (MFC) showed significant decreases (p <0.05) in Groups OVX, OVX-72, and OVX-100, as monthly ponderal variation (MPV) showed significant differences (p <0.005), particularly Group OVX-72 vs. Group OVX. However, none of the PEMFs used produced an amelioration of castration-induced osteopenia by changing the balance between bone resorption and formation. As opposed to PEMFs at 50 and 100 Hz, the effect on bone of PEMFs at 72 Hz could have been hidden by systemic application of an instrument conceived for local therapy only.

Original languageEnglish
Pages (from-to)119-131
Number of pages13
JournalElectromagnetic Biology and Medicine
Issue number2
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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